Stern D, Vasey H
Département de chirurgie, Hôpital cantonal universitaire, Genève.
Schweiz Med Wochenschr. 1987 Dec 19;117(51):2084-8.
202 patients undergoing surgery involving the lower limbs were given antithrombotic treatment for at least 21 days, or until they had regained full mobility. Following subcutaneous prophylaxis with a combination of heparin and dihydroergotamine, two oral regimens were compared in a controlled and randomized prospective study. The first treatment consisted of a combination of acetylsalicylic acid (ASA) and dihydroergotamine (DHE), and the second of acenocoumarol. The radiofibrinogen uptake test was carried out in high-risk patients (i.e. those undergoing hip surgery) to detect deep-vein thrombosis. No statistically significant difference was found between the two groups. However, the ASA/DHE combination enjoyed better patient acceptance and was much easier to use.
202例接受下肢手术的患者接受了至少21天的抗血栓治疗，或直至完全恢复活动能力。在采用肝素和双氢麦角胺联合进行皮下预防之后，在一项对照随机前瞻性研究中对两种口服治疗方案进行了比较。第一种治疗方案为乙酰水杨酸（ASA）和双氢麦角胺（DHE）联合使用，第二种为醋硝香豆素。对高危患者（即接受髋关节手术的患者）进行放射性纤维蛋白原摄取试验以检测深静脉血栓形成。两组之间未发现统计学上的显著差异。然而，ASA/DHE联合用药的患者接受度更高，且使用起来更为便捷。
