Hug C, Reutter F W, Gloor F
Medizinische Klinik B, Kantonsspital St. Gallen.
Schweiz Med Wochenschr. 1987 Dec 26;117(52):2118-21.
Of 123 patients with sarcoidosis observed from 1971 to 1986, 4 had histologically proven renal involvement. Hypercalcemia was present in all of these 4 patients, hypercreatinemia in 3 and urolithiasis in one. Histologically renal interstitial nephritis or fibrosis was found in all 4 cases, and 3 cases showed sarcoid-like renale granulomas. In addition, nephrocalcinosis or mesangioproliferative glomerulonephritis was present in one patient each. Corticosteroid therapy corrected hypercalcemia in 3 patients and improved renal function in the patient with glomerulonephritis and in the case with interstitial fibrosis. One patient died of granulomatous myocarditis, renal insufficiency having been unaffected by corticosteroids.
在1971年至1986年间观察的123例结节病患者中，有4例经组织学证实有肾脏受累。这4例患者均有高钙血症，3例有血肌酐升高，1例有尿路结石。组织学检查发现所有4例均有肾间质性肾炎或纤维化，3例显示类结节性肾肉芽肿。此外，1例患者有肾钙质沉着症，1例有系膜增生性肾小球肾炎。皮质类固醇治疗使3例患者的高钙血症得到纠正，并改善了肾小球肾炎患者和间质性纤维化患者的肾功能。1例患者死于肉芽肿性心肌炎，肾功能不全未受皮质类固醇影响。
