Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Exp Med Biol. 2021;1291:295-326. doi: 10.1007/978-3-030-56153-6_18.
Gastrointestinal (GI) diseases are highly prevalent worldwide, with considerable morbidity and mortality. Curcumin has been used for many years as a plant-derived product for the management of various conditions such as abdominal pain and poor digestion. This systematic review was undertaken with the aim of investigating the effect of curcumin or turmeric supplementation on GI diseases. A comprehensive systematic search was conducted in PubMed, Scopus, Web of Science and Google Scholar up to March 2020 to identify clinical trials assessing the effect of curcumin/turmeric alone or in combination with other herbs or nutrients on GI diseases. Twenty-one studies comprising 1478 GI patients were included in the study. Four out of seven studies showed a beneficial effect of curcumin/turmeric supplementation on irritable bowel syndrome (IBS) and six out of seven showed positive effects of these herbs on ulcerative colitis. Two out of four studies highlighted the potential role of curcumin/turmeric in eradication of H. pylori infection. Both studies conducted on peptic ulcer disease and two out of four studies performed on Crohn's disease demonstrated positive effects of curcumin/turmeric supplementation. One study showed curcumin supplementation had no effect on familial adenomatous polyposis. However, in another study, curcumin had favorable effects on proctosigmoiditis. Nine studies reported some minor adverse effects. The results of this systematic review suggest a beneficial effect of curcumin/turmeric supplementation on the management of GI diseases. More randomized clinical controlled trials are needed to confirm these results.
胃肠道（GI）疾病在全球范围内非常普遍，发病率和死亡率都相当高。姜黄素作为一种植物衍生产品，多年来一直被用于治疗各种疾病，如腹痛和消化不良。本系统评价旨在研究姜黄素或 turmeric 补充剂对胃肠道疾病的影响。我们对 PubMed、Scopus、Web of Science 和 Google Scholar 进行了全面的系统检索，截至 2020 年 3 月，以确定评估姜黄素/ turmeric 单独或与其他草药或营养素联合用于胃肠道疾病的临床试验。共有 21 项研究纳入了 1478 名胃肠道疾病患者。在 7 项研究中有 4 项显示姜黄素/ turmeric 补充剂对肠易激综合征（IBS）有有益的影响，而 7 项研究中有 6 项显示这些草药对溃疡性结肠炎有积极的影响。有 2 项研究强调了姜黄素/ turmeric 在根除幽门螺杆菌感染方面的潜在作用。在两项关于消化性溃疡病的研究和四项关于克罗恩病的研究中，有两项研究显示姜黄素/ turmeric 补充剂有积极的影响。一项研究表明姜黄素补充剂对家族性腺瘤性息肉病没有影响。然而，在另一项研究中，姜黄素对直肠乙状结肠炎有良好的疗效。有 9 项研究报告了一些轻微的不良反应。本系统评价的结果表明，姜黄素/ turmeric 补充剂对胃肠道疾病的治疗有有益的影响。需要更多的随机对照临床试验来证实这些结果。
