Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Biofactors. 2019 May;45(3):304-317. doi: 10.1002/biof.1504. Epub 2019 Apr 24.
Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019.
姜黄素是从姜黄中分离得到的一种天然酚类化合物，具有多种药理作用，包括抗炎、抗菌、抗氧化和抗癌特性。然而，由于其疏水性、低肠道吸收和快速代谢，姜黄素的生物利用度有限。因此，需要提高其生物利用度和在水中的溶解度，以增加这种生物活性化合物的药理作用。一种策略是用过渡金属对姜黄素进行复合，以解决上述问题。姜黄素可以与各种金属离子螯合，形成姜黄素的金属配合物，其效果可能比单独使用姜黄素更好。在抗氧化、抗癌和抗菌活性以及阿尔茨海默病治疗方面，金属姜黄素配合物已经取得了有希望的结果。本文综述了姜黄素-金属配合物的特性和生物学性质。© 2019 BioFactors，45（3）：304-317，2019。
