钪对用于骨科应用的β型 Ti-24Nb-38Zr-2Mo 合金的机械性能、腐蚀行为、摩擦磨损性能和细胞毒性的影响。
Impact of scandium on mechanical properties, corrosion behavior, friction and wear performance, and cytotoxicity of a β-type Ti-24Nb-38Zr-2Mo alloy for orthopedic applications.
机构信息
School of Materials Science and Engineering, Xiangtan University, Xiangtan 411105, China; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.
School of Materials Science and Engineering, Xiangtan University, Xiangtan 411105, China.
出版信息
Acta Biomater. 2021 Oct 15;134:791-803. doi: 10.1016/j.actbio.2021.07.061. Epub 2021 Jul 28.
β-type titanium (Ti) alloys have been extensively investigated as orthopedic implant materials due to their unique combination of low elastic modulus, high specific strength, corrosion resistance, and biocompatibility. In this study the mechanical properties, corrosion behavior, friction and wear performance, and cytotoxicity of β-type Ti-24Nb-38Zr-2Mo (TNZM) and Ti-24Nb-38Zr-2Mo-0.1Sc (TNZMS) have been comparatively investigated for orthopedic applications. Cold-rolling (CR) and cold-rolling plus solution-treatment (CR+ST) were performed on the as-cast (AC) alloys and their microstructures and material properties were characterized. The impact of Sc addition on the mechanical and corrosion properties, friction and wear behavior, and in vitro cytocompatibility of the TNZMS alloy was assessed. The CR+ST TNZMS alloy exhibited the best combination of properties among all the alloy samples, with a yield strength of 780 MPa, ultimate strength of 809 MPa, elongation of 19%, Young's modulus of 65.4 GPa, and hardness of 265 HV. Electrochemical testing in Hanks' Solution indicated that the CR+ST TNZMS sample also showed the highest corrosion resistance with a corrosion potential of -0.234 V, corrosion current density of 0.07 µA/cm, and corrosion rate of 1.2 µm/y. Friction and wear testing revealed that the TNZMS alloy showed higher wear resistance compared to the TNZM alloy and the wear resistance of the different samples was ranked CR > CR+ST > AC. Finally, both the CR+ST TNZM and TNZMS showed no-cytotoxicity towards MG-63 cells and the TNZMS exhibited slightly higher cytocompatibility than the TNZM alloy. STATEMENT OF SIGNIFICANCE: This work reports the β-type Ti-24Nb-38Zr-2Mo (TNZM) and Ti-24Nb-38Zr-2Mo-0.1Sc (TNZMS) alloys fabricated by as-cast (AC), cold-rolling (CR), and cold-rolling plus solution-treatment (CR+ST) for potential orthopedic applications. The experimental results showed that the TNZMS alloy exhibited significantly enhanced mechanical, wear, and corrosion properties than those of TNZM alloy; and the CR+ST TNZMS possess a unique combination of the best mechanical and corrosion properties including a yield strength of 780 MPa, ultimate strength of 809 MPa, elongation of 19%, Young's modulus of 65.4 GPa, and corrosion rate of 1.2 µm/y in Hanks' Solution. Both the CR+ST TNZM and TNZMS alloys exhibited non-cytotoxicity towards MG-63 cells and TNZMS showed a higher cytocompatibility than that of TNZM.
β 型钛（Ti）合金因其独特的低弹性模量、高比强度、耐腐蚀性和生物相容性而被广泛研究作为骨科植入材料。本研究比较了医用β 型 Ti-24Nb-38Zr-2Mo（TNZM）和 Ti-24Nb-38Zr-2Mo-0.1Sc（TNZMS）的力学性能、腐蚀行为、摩擦磨损性能和细胞毒性，以期将其应用于骨科领域。对铸态（AC）合金进行冷轧（CR）和冷轧加固溶处理（CR+ST），并对其微观结构和材料性能进行了表征。评估了 Sc 对 TNZMS 合金力学性能和腐蚀性能、摩擦磨损性能以及体外细胞相容性的影响。结果表明，经过 CR+ST 的 TNZMS 合金具有最佳的综合性能，其屈服强度为 780MPa，极限强度为 809MPa，伸长率为 19%，杨氏模量为 65.4GPa，硬度为 265HV。在 Hank's 溶液中的电化学测试表明，经过 CR+ST 的 TNZMS 样品具有最高的耐腐蚀性，其腐蚀电位为-0.234V，腐蚀电流密度为 0.07µA/cm，腐蚀速率为 1.2µm/y。摩擦磨损试验表明，与 TNZM 合金相比，TNZMS 合金具有更高的耐磨性，不同样品的耐磨性顺序为 CR>CR+ST>AC。最后，CR+ST 的 TNZM 和 TNZMS 对 MG-63 细胞均无细胞毒性，且 TNZMS 合金的细胞相容性略高于 TNZM 合金。
意义陈述
本工作报道了β 型 Ti-24Nb-38Zr-2Mo（TNZM）和 Ti-24Nb-38Zr-2Mo-0.1Sc（TNZMS）合金，通过铸态（AC）、冷轧（CR）和冷轧加固溶处理（CR+ST）进行制备，以期用于潜在的骨科应用。实验结果表明，与 TNZM 合金相比，TNZMS 合金具有显著增强的力学性能、磨损性能和腐蚀性能；经过 CR+ST 的 TNZMS 具有独特的最佳综合力学性能和腐蚀性能，包括屈服强度为 780MPa，极限强度为 809MPa，伸长率为 19%，杨氏模量为 65.4GPa，在 Hank's 溶液中的腐蚀速率为 1.2µm/y。CR+ST 的 TNZM 和 TNZMS 合金对 MG-63 细胞均无细胞毒性，且 TNZMS 合金的细胞相容性高于 TNZM 合金。
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