Dong Zhirao, Lu Xinyue, Zhang Weiyu, Tang Shaolun, Liu Hao, Zhang Ruichu, Liang Yuqi, Liu Xiaomo, Zhang Yunfan
Department of Orthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No. 22, Zhongguancun South Avenue, Haidian District, Beijing 100081, P.R. China.
Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No. 22, Zhongguancun South Avenue, Haidian District, Beijing 100081, P.R. China.
iScience. 2025 Jul 26;28(9):113220. doi: 10.1016/j.isci.2025.113220. eCollection 2025 Sep 19.
A confluence of factors, including the incompatibility of conventional materials with the oral environment, inadequate dynamic response, and insufficient multi-objective synergy, hinders precise diagnosis and efficient treatment in contemporary stomatology. Due to their unique electronic configuration and multivalent properties, rare earth elements (REEs) have shown excellent optical response, enzyme simulation activity, antibacterial efficacy, and biological regulation potential. These attributes offer a promising path for developing a new generation of oral functional materials. To align the unique properties of REEs and the clinical demands, this article summarizes the current knowledge of physicochemical properties and biological functions of REEs, and provides a comprehensive overview of the cutting-edge applications of rare-earth-based materials in oral medicine. We anticipate that this review will enhance the understanding of the interdisciplinary value of rare-earth-based materials in stomatology, thereby contributing to the improvement of future oral healthcare.
包括传统材料与口腔环境不兼容、动态响应不足以及多目标协同作用不够等在内的多种因素，阻碍了当代口腔医学中的精确诊断和有效治疗。稀土元素（REEs）因其独特的电子构型和多价特性，展现出优异的光学响应、酶模拟活性、抗菌功效及生物调节潜力。这些特性为开发新一代口腔功能材料提供了一条有前景的途径。为使稀土元素的独特性能与临床需求相匹配，本文总结了目前关于稀土元素物理化学性质和生物学功能的知识，并全面概述了稀土基材料在口腔医学中的前沿应用。我们期望这篇综述能增进对稀土基材料在口腔医学中跨学科价值的理解，从而有助于改善未来的口腔医疗保健。
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