Pitha J V, Hemstreet G P, Asal N R, Petrone R L, Trump B F, Silva F G
Department of Pathology, Veterans Administration Medical Center, Oklahoma City, OK 73104.
Toxicol Ind Health. 1987 Dec;3(4):491-506. doi: 10.1177/074823378700300404.
A blinded, retrospective study of histological sections from ten hydrocarbon-exposed and twenty unexposed nephrectomized renal cell carcinoma cases was conducted to evaluate the histopathologic features present in the apparently normal kidney parenchyma removed with the tumor. Tissue sections from each of the thirty cases were independently reviewed by three consulting pathologists and scored using well defined criteria. Occupational hydrocarbon exposure indices were developed by a team of industrial hygienists and applied to the detailed occupational history of each exposed case. A positive correlation was observed between age and the total renal pathology score (rs = .40, p less than .03). No correlation was found between indices of occupational hydrocarbon exposure and renal pathology scores among exposed cases. No significant differences in renal pathology scores were noted when exposed cases were matched to unexposed cases by age, sex, and race. These results are limited by the inclusion of only cases with historical hydrocarbon exposures. It is recommended that a follow-up study be conducted, utilizing sensitive quantitative methods, to define what, if any, cytopathologic renal effects occur in conjunction with current occupational exposures to hydrocarbons.
对10例有碳氢化合物暴露史和20例无暴露史的肾切除肾细胞癌病例的组织切片进行了一项双盲回顾性研究，以评估与肿瘤一并切除的看似正常的肾实质中存在的组织病理学特征。30例病例中的每例组织切片均由三名会诊病理学家独立审查，并使用明确的标准进行评分。一组工业卫生学家制定了职业碳氢化合物暴露指数，并将其应用于每例暴露病例的详细职业史。观察到年龄与肾脏病理总评分之间存在正相关（rs = 0.40，p < 0.03）。在暴露病例中，未发现职业性碳氢化合物暴露指数与肾脏病理评分之间存在相关性。当按年龄、性别和种族将暴露病例与未暴露病例进行匹配时，未发现肾脏病理评分有显著差异。这些结果因仅纳入有既往碳氢化合物暴露史的病例而受到限制。建议进行一项后续研究，采用敏感的定量方法，以确定当前职业性接触碳氢化合物是否会伴发任何细胞病理学肾脏效应。
