Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.
Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany; German Center for Infection Research, DZIF, partner site Heidelberg, Germany.
Trends Parasitol. 2021 Sep;37(9):777-779. doi: 10.1016/j.pt.2021.07.008. Epub 2021 Jul 28.
Plasmodium merozoites invade erythrocytes in a stepwise manner through ligand binding, calcium signaling, and membrane deformation. Using a recently developed light-sheet microscope, Geoghegan et al. investigated invasion with unprecedented temporal resolution. Their spectacular footage revealed roles for host cell cholesterol and pore formation at the parasite-host cell interface.
疟原虫裂殖子以逐步的方式通过配体结合、钙离子信号和膜变形侵入红细胞。利用最近开发的光片显微镜，Geoghegan 等人以空前的时间分辨率研究了入侵过程。他们的精彩视频揭示了宿主细胞胆固醇和在寄生虫-宿主细胞界面形成孔的作用。
