Department of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan.
Department of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Pediatr Neonatol. 2021 Nov;62(6):647-654. doi: 10.1016/j.pedneo.2021.06.008. Epub 2021 Jul 17.
Blood glucose and serum sodium abnormalities in very low birth weight infants may cause increased morbidity and mortality, but data regarding the long-term outcomes are limited. This study aimed to investigate the association between the peak and nadir blood glucose and serum sodium levels and neurodevelopmental outcomes in very low birth weight infants.
A single-center retrospective medical record of 284 infants with birth weight<1500 g born between February 1, 2011 and January 31, 2015 was reviewed. We analyzed the correlation between peak and nadir blood glucose and serum sodium levels during hospitalization and Bayley Scales of Infant and Toddler Development, third edition at 6, 12, and 24 months of corrected age.
A total of 284 very low birth weight premature infants were eligible, and 223, 208, and 188 patients were assessed at 6, 12, and 24 months of corrected age, respectively. Multiple linear regression analysis with generalized estimating equations showed that the BSID-III cognitive scores were significantly lower in the peak serum sodium group when sodium was ≧150 mmol/L (95% confidence interval -11.681 to -0.822) than when sodium did not exceed 150 mmol/L.
A peak serum sodium of ≧150 mmol/L is associated with poor cognitive outcomes in very low birth weight infants. Further studies are necessary to determine if this association is causal or an expression of disease severity.
极低出生体重儿的血糖和血清钠异常可能导致发病率和死亡率增加，但关于长期结局的数据有限。本研究旨在探讨极低出生体重儿住院期间血糖和血清钠峰值和谷值与神经发育结局的关系。
回顾性分析 2011 年 2 月 1 日至 2015 年 1 月 31 日期间出生体重<1500 g 的 284 例单中心婴儿病历。我们分析了住院期间血糖和血清钠峰值和谷值与贝利婴幼儿发育量表第三版在矫正年龄 6、12 和 24 个月时的相关性。
共有 284 例极低出生体重早产儿符合条件，分别有 223、208 和 188 例患者在矫正年龄 6、12 和 24 个月时进行了评估。使用广义估计方程的多元线性回归分析显示，血清钠≧150 mmol/L 时（95%置信区间 -11.681 至 -0.822），BSID-III 认知评分显著低于血清钠不超过 150 mmol/L 时。
血清钠峰值≧150 mmol/L 与极低出生体重儿认知结局不良有关。需要进一步研究以确定这种关联是因果关系还是疾病严重程度的表现。
