Board of education, Japan Society of Obstetrics and Gynecology, Tokyo, Japan.
Department of Obstetrics and Gynecology, Juntendo University, Tokyo, Japan.
J Obstet Gynaecol Res. 2021 Nov;47(11):3761-3766. doi: 10.1111/jog.14952. Epub 2021 Aug 1.
At the 73rd Annual Congress of the Japan Society of Obstetrics and Gynecology, young doctors from Japan and South Korea made presentations on the present condition of risk-reducing surgery for hereditary breast and ovarian cancer (RRSO) in their respective country. RRSO was insured in Japan in April 2020, whereas in South Korea, it was insured 7 years earlier in 2013. In Japan, certification criteria have been set for facilities that perform RRSO, and the number of facilities is increasing, but regional disparities still exist in its distribution. The number of gBRCA1/2 testing facilities is larger, and the cost is more affordable in South Korea than in Japan. Additionally, South Korea provides genetic counseling to a wider range of relatives compared to Japan. In the future, as the indications for the gBRCA1/2 test have expanded as a companion diagnostic for the use of PARP inhibitors, it is expected that the number of candidates for the gBRCA1/2 mutation test and RRSO will increase in Japan. It is important to increase the number of BRCA tests while maintaining the quality of genetic counseling in order to provide adequate information on BRCA mutations and RRSO for patients to support their decision. For the development of hereditary breast and ovarian cancer (HBOC) medical care, it is necessary to publish a nationwide database in Japan and continue to analyze and discuss the data based on the results.
在第 73 届日本妇产科协会年会上,来自日本和韩国的年轻医生介绍了本国遗传性乳腺癌和卵巢癌(HBOC)风险降低手术(RRSO)的现状。RRSO 于 2020 年 4 月在日本获得保险,而韩国早在 2013 年就获得了保险。日本为实施 RRSO 的医疗机构设定了认证标准,实施 RRSO 的医疗机构数量不断增加,但分布仍存在地区差异。韩国的 gBRCA1/2 检测设施更多,成本也比日本更实惠。此外,韩国比日本为更多的亲属提供遗传咨询。随着 gBRCA1/2 检测作为 PARP 抑制剂使用的伴随诊断的适应证扩大,预计日本接受 gBRCA1/2 突变检测和 RRSO 的候选人数将会增加。为了为患者提供有关 BRCA 突变和 RRSO 的充分信息以支持他们的决策,在维持遗传咨询质量的同时增加 BRCA 检测数量非常重要。为了开展遗传性乳腺癌和卵巢癌(HBOC)的医疗护理,有必要在日本发布全国性数据库,并根据结果继续分析和讨论数据。