法国的人乳头瘤病毒（HPV）疫苗接种率（VCR）：一项法国索赔数据研究。

Human papillomavirus (HPV) vaccine coverage rates (VCRs) in France: A French claims data study.

机构信息

PELyon, PharmacoEpidemiologie Lyon, France.

MSD France, Paris, France.

出版信息

Vaccine. 2021 Aug 23;39(36):5129-5137. doi: 10.1016/j.vaccine.2021.07.054. Epub 2021 Jul 30.

DOI:10.1016/j.vaccine.2021.07.054

PMID:34334252

Abstract

BACKGROUND

The French Cancer Plan 2014-2019 had a target of 60% HPV vaccine coverage. The PAPILLON study investigated the annual age-specific vaccination initiation rates and cumulative partial and complete vaccination rates in France from 2017 to 2022. It also identified the factors associated with vaccination in different age groups and those associated with the type of completion of the vaccination scheme (partial vs full vaccination).

METHODS

For this publication, all females recorded in the French National Claims database who initiated HPV vaccination between 1 July 2007 and 31 December 2018 and were aged between 11 and 19 years at initiation were included. Annual HPV vaccination initiation rates were estimated in 11- to 14-year-old (target population) and 15- to 19-year-old females (catch-up). Cumulative vaccine coverage rates (VCRs) were estimated among those who were 15, 16, 20 and 21 years old. Partial vaccination was defined by dispensing of at least one dose of HPV vaccine by the pharmacy, while full vaccination was defined by two or three doses dispensed by a pharmacy over an 18-month period, according to current French recommendations based on the age at vaccination initiation.

RESULTS

Among the 465,629 females who initiated HPV vaccination in 2017 or 2018, the initiation rate increased from 7.7 to 11.1% in 11- to 14-year-old girls and from 4.5 to 6.5% in 15- to 19-year-old females. In 2017 and 2018, the cumulative VCRs for partial vaccination by age 15 were 28.2% and 32.8%, respectively, while by age 20, they were 41.6% and 38.8%. The cumulative VCRs for full vaccination were 15.6% and 18.6% by age 16, while they were 25.9 and 23.6% by age 20. HPV vaccination initiation and completion were strongly associated with the use of health services.

CONCLUSION

Overall, the HPV VCR substantively increased between 2017 and 2018, which is positive evidence of the resumption of vaccination. Updates in 2022 should confirm these results.

摘要

背景

2014-2019 年法国癌症计划的目标是实现 60%的 HPV 疫苗接种覆盖率。PAPILLON 研究调查了 2017 年至 2022 年期间法国按年龄特异性的年度疫苗接种起始率以及部分和完全疫苗接种的累积率。它还确定了不同年龄组中与接种相关的因素，以及与疫苗接种方案完成类型（部分接种与完全接种）相关的因素。

方法

本研究中，将纳入所有在 2007 年 7 月 1 日至 2018 年 12 月 31 日期间在法国国家索赔数据库中记录的开始 HPV 疫苗接种且起始年龄在 11 至 19 岁之间的女性。11 至 14 岁（目标人群）和 15 至 19 岁的女性中按年龄特异性估计 HPV 疫苗接种起始率。在 15、16、20 和 21 岁时估计疫苗累积覆盖率（VCR）。根据当前基于接种起始年龄的法国建议，部分接种定义为药房至少分发一剂 HPV 疫苗，而完全接种定义为药房在 18 个月内分发两剂或三剂。

结果

在 2017 年或 2018 年开始 HPV 疫苗接种的 465629 名女性中，11 至 14 岁女孩的起始率从 7.7%增加到 11.1%，15 至 19 岁女性的起始率从 4.5%增加到 6.5%。在 2017 年和 2018 年，15 岁时部分接种的累积 VCR 分别为 28.2%和 32.8%，而 20 岁时的 VCR 分别为 41.6%和 38.8%。16 岁时完全接种的累积 VCR 分别为 15.6%和 18.6%，而 20 岁时的 VCR 分别为 25.9%和 23.6%。HPV 疫苗接种的起始和完成与卫生服务的使用密切相关。