MetroHealth, Department of Radiology, Cleveland, OH, USA.
Case Western Reserve University, Department of Biomedical Engineering, Center for Computational Imaging & Personalized Diagnostics, Cleveland, OH, USA.
J Alzheimers Dis. 2021;83(1):423-433. doi: 10.3233/JAD-210308.
Histopathologic studies have demonstrated differential amyloid-β (Aβ) burden between cortical sulci and gyri in Alzheimer's disease (AD), with sulci having a greater Aβ burden.
To characterize Aβ deposition in the sulci and gyri of the cerebral cortex in vivo among subjects with normal cognition (NC), mild cognitive impairment (MCI), and AD, and to evaluate if these differences could improve discrimination between diagnostic groups.
T1-weighted 3T MR and florbetapir (amyloid) positron emission tomography (PET) data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI). T1 images were segmented and the cortex was separated into sulci/gyri based on pial surface curvature measurements. T1 images were registered to PET images and regional standardized uptake value ratios (SUVr) were calculated. A linear mixed effects model was used to analyze the relationship between clinical variables and amyloid PET SUVr measurements in the sulci/gyri. Receiver operating characteristic (ROC) analysis was performed to define amyloid positivity. Logistic models were used to evaluate predictive performance of clinical diagnosis using amyloid PET SUVr measurements in sulci/gyri.
719 subjects were included: 272 NC, 315 MCI, and 132 AD. Gyral and sulcal Aβ increased with worsening cognition, however there was a greater increase in gyral Aβ. Females had a greater gyral and sulcal Aβ burden. Focusing on sulcal and gyral Aβ did not improve predictive power for diagnostic groups.
While there were significant differences in Aβ deposition in cerebral sulci and gyri across the AD spectrum, these differences did not translate into improved prediction of diagnosis. Females were found to have greater gyral and sulcal Aβ burden.
组织病理学研究表明，阿尔茨海默病（AD）患者大脑皮质脑沟和脑回之间存在β淀粉样蛋白（Aβ）负荷的差异，脑沟的 Aβ 负荷更大。
在认知正常（NC）、轻度认知障碍（MCI）和 AD 患者中，对大脑皮质脑沟和脑回中的 Aβ 沉积进行体内特征描述，并评估这些差异是否可以提高对诊断组的区分能力。
ADNI 获得了 3T MRI 和氟代苯丙氨酸（淀粉样蛋白）正电子发射断层扫描（PET）数据。对 T1 图像进行分割，根据脑回表面曲率测量值将大脑皮质分为脑沟/脑回。将 T1 图像与 PET 图像配准，并计算区域标准化摄取值比（SUVr）。采用线性混合效应模型分析临床变量与脑沟/脑回中淀粉样 PET SUVr 测量值之间的关系。采用受试者工作特征（ROC）分析确定淀粉样蛋白阳性。使用逻辑模型评估脑沟/脑回中淀粉样 PET SUVr 测量值对临床诊断的预测性能。
共纳入 719 名受试者：272 名 NC、315 名 MCI 和 132 名 AD。随着认知能力的恶化，脑回和脑沟的 Aβ 增加，但脑回的 Aβ 增加更为明显。女性脑回和脑沟的 Aβ 负担更重。关注脑沟和脑回的 Aβ 并不能提高对诊断组的预测能力。
虽然在 AD 谱中大脑皮质脑沟和脑回之间的 Aβ 沉积存在显著差异，但这些差异并不能转化为对诊断的改善预测。女性发现脑回和脑沟的 Aβ 负担更重。
