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肠黏膜相关弥漫大 B 细胞淋巴瘤合并乳糜泻一例并文献复习

Epstein-Barr Virus-positive Intestinal Diffuse Large B-cell Lymphoma in a Japanese Patient with Celiac Disease: First Reported Case and a Literature Review.

机构信息

Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.

Division of Medical Oncology, Hematology and Infectious Diseases Faculty of Medicine, Fukuoka University, Japan.

出版信息

Intern Med. 2022 Feb 1;61(3):329-334. doi: 10.2169/internalmedicine.7876-21. Epub 2021 Jul 30.

DOI:10.2169/internalmedicine.7876-21
PMID:34334570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8866777/
Abstract

A 60-year-old Japanese woman was diagnosed with celiac disease (CeD) and treated with a gluten-free diet. For five years, she had a good clinical course. However, she complained of inappetence and nausea. Colonoscopy revealed ulcerative tumors in the terminal ileum. A histological examination of biopsy specimens from the ulcerative tumor showed diffuse infiltration of large atypical lymphocytes. Immunohistologically, the atypical lymphoid cells were positive for cluster of differentiation (CD) 10 and CD20. Many Epstein-Barr virus-encoded small RNA (EBER)-positive atypical lymphocytes were detected by in situ hybridization. This represents the first reported case of Epstein-Barr virus-positive intestinal diffuse large B-cell lymphoma complicated with CeD.

摘要

一位 60 岁的日本女性被诊断患有乳糜泻（CeD），并接受了无麸质饮食治疗。五年来，她的临床病程良好。然而，她主诉食欲不振和恶心。结肠镜检查显示末端回肠有溃疡性肿瘤。对溃疡性肿瘤活检标本的组织学检查显示，大异型淋巴细胞弥漫浸润。免疫组织化学检查显示，异型淋巴细胞 CD10 和 CD20 阳性。原位杂交检测到许多 Epstein-Barr 病毒编码的小 RNA（EBER）阳性异型淋巴细胞。这是首例报道的伴有 CeD 的 Epstein-Barr 病毒阳性肠弥漫性大 B 细胞淋巴瘤病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/cee5b96f81b4/1349-7235-61-0329-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/af184de091dc/1349-7235-61-0329-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/132052fd0334/1349-7235-61-0329-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/e744060f8601/1349-7235-61-0329-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/5addaf8c5cf7/1349-7235-61-0329-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/cee5b96f81b4/1349-7235-61-0329-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/af184de091dc/1349-7235-61-0329-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/132052fd0334/1349-7235-61-0329-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/e744060f8601/1349-7235-61-0329-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/5addaf8c5cf7/1349-7235-61-0329-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d573/8866777/cee5b96f81b4/1349-7235-61-0329-g005.jpg

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Am J Surg Pathol. 2020 Sep;44(9):1173-1183. doi: 10.1097/PAS.0000000000001499.
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A case of celiac disease with type I enteropathy-associated T-cell lymphoma in a Japanese male patient.一名日本男性患者患腹腔疾病合并I型肠病相关T细胞淋巴瘤的病例。
Immunol Med. 2019 Sep;42(3):142-147. doi: 10.1080/25785826.2019.1673031. Epub 2019 Oct 11.
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Diffuse large B-cell lymphoma of the small intestine in a patient with refractory coeliac disease.
一名患有难治性乳糜泻的患者发生小肠弥漫性大B细胞淋巴瘤。
Malays J Pathol. 2019 Apr;41(1):65-69.
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Clinicopathological analysis of primary intestinal diffuse large B-cell lymphoma: Prognostic evaluation of CD5, PD-L1, and Epstein-Barr virus on tumor cells.原发性肠道弥漫性大 B 细胞淋巴瘤的临床病理分析：肿瘤细胞 CD5、PD-L1 和 Epstein-Barr 病毒的预后评估。
Cancer Med. 2018 Dec;7(12):6051-6063. doi: 10.1002/cam4.1875. Epub 2018 Nov 18.
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EBV-Associated Lymphoproliferative Disorder and Hemophagocytic Lymphohistiocytosis in a Patient with Severe Celiac Disease.一名重症乳糜泻患者的EB病毒相关淋巴增殖性疾病和噬血细胞性淋巴组织细胞增生症
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Intestinal perforation secondary to intestinal diffuse large b-cell lymphoma in a patient with coeliac disease.一名患有乳糜泻的患者因肠道弥漫性大B细胞淋巴瘤继发肠穿孔。
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