Oruganti Venkata Ramanand, Sanjeevareddygari Shylaja, Munisekhar Manay Srinivas, Eppalapalli Sharath Kumar Reddy, Vishwakarma Raghu Vamshi, Ganji Kiran Kumar, Halkai Kiran R, Halkai Rahul
Department of Oral Pathology, SVS Institute of Dental Sciences, Mahabubnagar, Telangana, India.
Oral Pathology Division, Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka, Al Jouf, Saudi Arabia.
Case Rep Dent. 2021 Jul 17;2021:2093927. doi: 10.1155/2021/2093927. eCollection 2021.
Ameloblastoma is an epithelial odontogenic neoplasm with clinical and histological diversity. They are locally invasive tumors with 3 clinical variants such as solid, unicystic, and peripheral ameloblastomas, and the unicystic variant constitutes only 13%. Histologically, it shows diverse microscopic patterns that may occur isolated or in combination with other patterns. The granular cell variant accounts for 3.5% of all ameloblastoma cases. The eosinophilic granules seen in the cytoplasm of the tumor are thought to be lysosomes and presumably contribute to the pathogenesis of the tumor. Although such a phenomenon is rare in unicystic ameloblastoma, granular cell differentiation in solid multicystic ameloblastoma is a well-established phenomenon. In this paper, we present a unique case of unicystic ameloblastoma with granular cell differentiation with a brief review.
成釉细胞瘤是一种具有临床和组织学多样性的上皮性牙源性肿瘤。它们是局部侵袭性肿瘤，有实性、单囊性和外周性成釉细胞瘤3种临床变体，其中单囊性变体仅占13%。在组织学上，它表现出多种微观模式，这些模式可能单独出现或与其他模式组合出现。颗粒细胞变体占所有成釉细胞瘤病例的3.5%。肿瘤细胞质中可见的嗜酸性颗粒被认为是溶酶体，可能与肿瘤的发病机制有关。虽然这种现象在单囊性成釉细胞瘤中很少见，但在实性多囊性成釉细胞瘤中颗粒细胞分化是一种公认的现象。在本文中，我们报告了一例具有颗粒细胞分化的单囊性成釉细胞瘤的独特病例并进行简要回顾。
