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[用活性炭血液灌流治疗急性洋地黄中毒患者]

[Treatment of patients with acute digitalis poisoning by charcoal hemoperfusion].

作者信息

Marinov A

出版信息

Vutr Boles. 1987;26(5):46-50.

PMID:3433730
Abstract

10 patients with acute digitalis intoxication were treated by charcoal hemoperfusion. The patients had taken high toxic and lethal doses of digitalis drugs: 3 patients had taken 10 mg of (digitalin, 2 patients--7.5 mg of digoxin, 5 patients--10-25 mg of isolanid (ceglunat). 4 of the patients were with a heart disease and the other 6 patients did not have any heart disease. The charcoal hemoperfusion lasted 4 to 6 hours, in one female patient--2 hours. The mean minute volume was 100 to 150 ml/min, in some patients it reached up to 200 ml/min. The digoxin blood concentration was determined before and after the hemoperfusion in 4 patients and a decrease of 49% was found. 9 patients fully recovered and only one patient, a 70 years old women, who had not received antiarrhythmic treatment, died. Good results were also achieved in digitalin intoxications determined by the clinical course and the electrocardiographic data. The overall estimation of the method is that it is efficient and should be applied to patients with acute digitalis intoxication, always in combination with antidote, antiarrhythmic and cardioprotective treatment.

摘要

10例急性洋地黄中毒患者接受了活性炭血液灌流治疗。这些患者服用了高毒性和致死剂量的洋地黄药物:3例患者服用了10毫克洋地黄毒苷,2例患者服用了7.5毫克地高辛,5例患者服用了10 - 25毫克异他林(西格鲁钠)。其中4例患者患有心脏病,另外6例患者没有任何心脏病。活性炭血液灌流持续4至6小时,1例女性患者为2小时。平均每分钟血流量为100至150毫升/分钟,部分患者可达200毫升/分钟。对4例患者在血液灌流前后测定了地高辛血药浓度,发现下降了49%。9例患者完全康复,仅1例70岁未接受抗心律失常治疗的女性患者死亡。从临床病程和心电图数据来看,洋地黄毒苷中毒也取得了良好效果。该方法的总体评价是有效,应应用于急性洋地黄中毒患者,且始终要与解毒剂、抗心律失常和心脏保护治疗联合使用。

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