Pusic Kae Myriam, Won Lisa, Kraig Richard Paul, Pusic Aya Darinka
Department of Neurology, The University of Chicago, Chicago, Il 60637-1470, USA.
J Cell Immunol. 2021;3(4):215-225.
Environmental enrichment produces beneficial effects in the brain at genetic, molecular, cellular and behavior levels, and has long been studied as a therapeutic intervention for a wide variety of neurological disorders. However, the complexity of applying a robust environmental enrichment paradigm makes clinical use difficult. Accordingly, there has been increased interest in developing environmental enrichment mimetics, also known as enviromimetics. Here we review the benefits of environmental enrichment for migraine treatment, and discuss the potential of using extracellular vesicles derived from interferon gamma-stimulated dendritic cells as an effective mimetic.
环境富集在基因、分子、细胞和行为水平上对大脑产生有益影响，长期以来一直被作为多种神经疾病的治疗干预手段进行研究。然而，应用强大的环境富集模式的复杂性使得其临床应用困难。因此，人们对开发环境富集模拟物（也称为环境模拟物）的兴趣与日俱增。在这里，我们回顾了环境富集对偏头痛治疗的益处，并讨论了使用源自干扰素γ刺激的树突状细胞的细胞外囊泡作为有效模拟物的潜力。
