Rheumatology Unit, Hospital Universitario Fundación Alcorcon, Calle Budapest, 1, Alcorcon, 28922, Madrid, Spain.
Department of Preventive Medicine and Public Health, Rey Juan Carlos University, Madrid, Spain.
Osteoporos Int. 2022 Jan;33(1):149-159. doi: 10.1007/s00198-021-06079-y. Epub 2021 Aug 2.
Our aim was to analyze trends in fracture rates in SpA patients over an extended time period. Only an increase of axial fractures, more specifically vertebral fractures, is observed in SpA.
To analyze fracture incidence and trend in patients with spondyloarthritis (SpA) over an extended time period.
Retrospective observational population-based study with matched cohorts. Data from the Minimum Basic Data Set (MBDS) of Spain were reviewed. All SpA patient hospitalizations reported from 1999 to 2015 (SpA cohort) were analyzed. A control cohort (non-SpA cohort) matched by age, sex, region, and year of hospitalization was recruited. The age and sex-adjusted crude incidence rate was calculated for any fractures (axial and peripheral). Generalized linear models (GLM) were used for trend analysis. Association between fracture type and SpA (and its subtypes) was assessed using unconditional logistic regression models.
In the SpA cohort, the age and sex-adjusted rates per 100,000 inhabitants/year of total fracture and different types of fracture were 45.72 any fractures, 17.64 axial, and 28.02 peripheral; 29.42 osteoporotic (12.67 vertebra, 12.29 hip, 1.50 pelvis, 1.82 humerus and 2.09 radius). In the non-SpA cohort, they were 65.79 any, 12.08 axial, 51.52 peripheral; 31.17 osteoporotic (4.94 vertebra, 16.15 hip, 2.29 pelvis, 3.64 humerus, 5.38 radius). Between 1999 and 2015, the trend in incidence rate for total fracture and different types of fracture increased similarly for both cohorts. In the SpA cohort, an increase of axial fractures was found (AOR 1.444; 95%CI 1.297-1.609), and specifically of vertebral fractures (AOR 2.440; 95%CI 2.097-2.839). Other types of fractures did not increase.
Only an increase of axial fractures, more specifically vertebral fractures, is observed in SpA. Trend in incidence is similar in both cohorts.
我们的目的是分析强直性脊柱炎（SpA）患者在较长时间内骨折发生率的趋势。仅观察到 SpA 患者的轴向骨折（特别是椎体骨折）增加。
分析强直性脊柱炎（SpA）患者在较长时间内的骨折发生率和趋势。
回顾性观察性基于人群的研究，采用匹配队列。审查了西班牙最低基本数据集（MBDS）的数据。分析了 1999 年至 2015 年期间报告的所有 SpA 患者住院情况（SpA 队列）。通过年龄、性别、地区和住院年份匹配了一个对照组（非 SpA 队列）。计算了所有骨折（轴向和外周）的年龄和性别调整后的粗发生率。使用广义线性模型（GLM）进行趋势分析。使用非条件逻辑回归模型评估骨折类型与 SpA（及其亚型）之间的关联。
在 SpA 队列中，每 100,000 名居民/年的总骨折和不同类型骨折的年龄和性别调整率分别为 45.72 例任何骨折，17.64 例轴向骨折和 28.02 例外周骨折；29.42 例骨质疏松性骨折（12.67 例椎体骨折、12.29 例髋部骨折、1.50 例骨盆骨折、1.82 例肱骨骨折和 2.09 例桡骨骨折）。在非 SpA 队列中，这些数字分别为 65.79 例任何骨折，12.08 例轴向骨折，51.52 例外周骨折；31.17 例骨质疏松性骨折（4.94 例椎体骨折、16.15 例髋部骨折、2.29 例骨盆骨折、3.64 例肱骨骨折、5.38 例桡骨骨折）。1999 年至 2015 年间，两个队列的总骨折和不同类型骨折的发生率趋势均呈相似增加。在 SpA 队列中，发现轴向骨折增加（AOR 1.444；95%CI 1.297-1.609），特别是椎体骨折（AOR 2.440；95%CI 2.097-2.839）。其他类型的骨折并未增加。
仅观察到 SpA 患者的轴向骨折（特别是椎体骨折）增加。两个队列的发生率趋势相似。
