Katthagen B D
Orthopädische Universitätsklinik und Poliklinik Homburg/Saar.
Z Orthop Ihre Grenzgeb. 1987 Sep-Oct;125(5):559-66. doi: 10.1055/s-2008-1044755.
32 experiments in 22 rabbits were performed to investigate the bone regeneration after implantation of lone morphogenetic protein (BMP) in a 6 mm drill-hole of the distal femoral condyle. Two different BMP products have been used. A bone regeneration is to be observed partially at the surface of BMP, but in comparison to the control defects quantitatively insignificant. There is a significant difference in comparison to the bone substitutes Collapat and Pyrost, which proved well (highly significant more bone regeneration) in the same experimental set up. The biology of bone regeneration by; 1. osteogenic transplantation; 2. osteoinduction and 3. osteoconduction ist discussed in detail. According to the own experiments the principle of osteoinduction with BMP is not yet useful for general clinical practice. Probably the osteoinductive effect is disturbed by immunological processes. The extraction of pure "osteogenin" from BMP seems to be important.
在22只兔子身上进行了32项实验，以研究在股骨远端髁的6毫米钻孔中植入骨形态发生蛋白（BMP）后的骨再生情况。使用了两种不同的BMP产品。在BMP表面部分观察到骨再生，但与对照缺损相比，在数量上无显著意义。与骨替代物Collapat和Pyrost相比有显著差异，在相同实验设置中，这两种骨替代物效果良好（骨再生显著更多）。详细讨论了通过以下方式实现骨再生的生物学机制：1. 成骨移植；2. 骨诱导；3. 骨传导。根据自身实验，BMP的骨诱导原理尚未适用于一般临床实践。骨诱导作用可能受到免疫过程的干扰。从BMP中提取纯“骨生成素”似乎很重要。
