Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
Vector Borne Zoonotic Dis. 2021 Sep;21(9):653-658. doi: 10.1089/vbz.2020.2752. Epub 2021 Jul 30.
Morphea (localized scleroderma) is an inflammatory connective tissue disease. , as a causative factor, has been discussed controversially. The aim of this original study was to evaluate the frequency of IgM and IgG classes of anti-Borrelia antibodies in groups of morphea and psoriasis patients using the traditional ELISA method. Blood samples of 82 patients with morphea and 112 patients with psoriasis vulgaris were examined for the presence of IgM and IgG classes of anti-Borrelia antibodies (ELISA). IgM and IgG classes of anti-Borrelia antibodies were detected in 4% of blood samples taken from morphea patients, while 4.5% of blood samples from patients with psoriasis vulgaris. There is one major limitation in this study that could be addressed in future research. First, the study focused on the determination of IgM and IgG classes of anti-Borrelia antibodies as a risk factor for morphea, but other infectious agents also require further testing, such as Hepatitis B, Hepatitis C, and other viral or bacterial infections. The results of this study showed no significant relationship between Borrelia infection and morphea. Detection of IgM and IgG classes of anti-Borrelia antibodies is not recommended for routine diagnostics of patients with morphea at this time.
硬斑病（局限性硬皮病）是一种炎症性结缔组织病。作为致病因素，它一直存在争议。本原始研究的目的是使用传统 ELISA 方法评估硬斑病和银屑病患者组中 IgM 和 IgG 类抗伯氏疏螺旋体抗体的频率。检测了 82 例硬斑病患者和 112 例寻常型银屑病患者的血液样本中 IgM 和 IgG 类抗伯氏疏螺旋体抗体（ELISA）的存在情况。在硬斑病患者的血液样本中检测到 4%的 IgM 和 IgG 类抗伯氏疏螺旋体抗体，而在寻常型银屑病患者的血液样本中则检测到 4.5%。本研究存在一个主要的局限性，可以在未来的研究中解决。首先，该研究侧重于确定 IgM 和 IgG 类抗伯氏疏螺旋体抗体作为硬斑病的危险因素，但其他病原体也需要进一步检测，如乙型肝炎、丙型肝炎和其他病毒或细菌感染。本研究结果表明，伯氏疏螺旋体感染与硬斑病之间没有显著关系。目前不建议对硬斑病患者进行常规诊断检测 IgM 和 IgG 类抗伯氏疏螺旋体抗体。
