State Key Laboratory of Component-based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, PR China.
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, PR China.
J Ethnopharmacol. 2021 Nov 15;280:114446. doi: 10.1016/j.jep.2021.114446. Epub 2021 Jul 30.
The plants of the genus Nardostachys (Caprifoliaceae) have been used for a long history in different cultural systems of medicine, including Chinese, Ayurvedic, Korean folk medicine and Islamic, for treatments of disorders in nervous, digestive, cardiovascular and integumentary systems.
This review aims to provide comprehensive information on Nardostachys plants including botany update, traditional uses, data mining of uses in traditional Chinese medicine (TCM) and current Chinese medicinal patents, chemical constituents, pharmacological effects, toxicity and analytical method studies.
Studies of the genus Nardostachys were collected via Google Scholar and Baidu Scholar, ScienceDirect, SciFinder, Wiley Online Library, ACS Publications, NLM/NCBI, Web of Science, CNKI, WANFANG DATA, EMBASE, Huabeing database and Traditional Chinese Medicine Resource Network and libraries. Some local books, PhD or MS's dissertations were also included. The literatures cited in this review covered the period from 1962 to March 2021. The Plant List and Kew Herbarium Catalogue databases were used to authenticate the scientific name.
Botany description of Nardostachys genus is updated. Analysis of the literatures indicates that Nardostachys species are valuable herbs with therapeutic potentials for various disorders. Data mining on ancient TCM prescriptions and current Chinese medicinal patents containing Nardostachys revealed its common compatibility with other herbs in China. Phytochemical studies identified terpenoids and phenolic compounds as the main constituents in the genus Nardostachys and sesquiterpenoids as the major bioactive components. Experimental studies demonstrated that crude extracts, major fractions and the main constituents from Nardostachys species mainly exhibited pharmacological activities on nervous, digestive, cardiovascular and skin systems. Further, in vivo and in vitro toxicological studies demonstrated that Nardostachys plants showed either no or low toxicities, except at high doses. Finally, methods of qualitative and quantitative analyses on chemical constituents of genus Nardostachys were summarized, including TLC/HPTLC, GC and HPLC/UPLC methods, combined with common detectors including PDA, DAD and MS.
This review summarizes the progress on phytochemistry, pharmacology, toxicology and analytical methods of the genus Nardostachys. Studies demonstrate traditional uses of the genus Nardostachys, and reveal novel bioactive effects for clinical uses. These achievements expand our knowledge on the genus Nardostachys and its clinical value.
假百合科（Nardostachys）属植物在不同的医学文化体系中已有悠久的历史，包括中国、印度阿育吠陀、韩国民间医学和伊斯兰医学，用于治疗神经系统、消化系统、心血管系统和皮肤系统的疾病。
本综述旨在提供关于假百合科植物的综合信息，包括植物学更新、传统用途、中药（TCM）传统用途的数据挖掘和当前中药专利、化学成分、药理作用、毒性和分析方法研究。
通过 Google Scholar 和百度学术、ScienceDirect、SciFinder、Wiley Online Library、ACS 出版物、NLM/NCBI、Web of Science、CNKI、WANFANG DATA、EMBASE、Huabeing 数据库和中医药资源网络和图书馆收集假百合科属的研究。还包括一些本地书籍、博士或硕士论文。本综述引用的文献涵盖了 1962 年至 2021 年 3 月的时间段。使用植物名录和邱园标本馆目录数据库来验证学名。
更新了假百合科属的植物学描述。文献分析表明，假百合属植物是具有多种治疗潜力的有价值草药。对古代 TCM 方剂和当前含假百合属中药专利的数据挖掘表明，其在中国与其他草药的配伍较为常见。植物化学研究表明，萜类和酚类化合物是该属的主要成分，倍半萜类化合物是主要的生物活性成分。实验研究表明，假百合属植物的粗提取物、主要成分和主要成分主要对神经系统、消化系统、心血管系统和皮肤系统表现出药理活性。此外，体内和体外毒理学研究表明，除高剂量外，假百合属植物表现出无毒或低毒性。最后，总结了假百合属植物化学成分的定性和定量分析方法，包括 TLC/HPTLC、GC 和 HPLC/UPLC 方法，并结合常见的检测器，包括 PDA、DAD 和 MS。
本综述总结了假百合属植物的植物化学、药理学、毒理学和分析方法的研究进展。研究表明了该属植物的传统用途，并揭示了其用于临床的新的生物活性作用。这些成就扩展了我们对假百合属植物的认识及其临床价值。
