Archaea Physiology & Biotechnology Group, Department of Functional and Evolutionary Ecology, Universität Wien, Wien, Austria.
Institute for Environmental Biotechnology, Department IFA Tulln, University of Natural Resources and Life Sciences, Wien, Austria.
Curr Opin Biotechnol. 2022 Feb;73:74-80. doi: 10.1016/j.copbio.2021.07.010. Epub 2021 Jul 31.
In natural microbial ecosystems the metabolic diversity of the organisms enables interaction among the community members and allows them to engage in syntrophic interactions. With regard to biotechnology, artificial microbial consortium engineering is used to improve productivities and yields of bioprocesses. However, to achieve supreme productivity or efficiency at industrial scale, defined ecosystems must be physiologically well-selected to meet eco-biotechnological demands. Here, we present an artificial microbial consortia design and engineering pipeline for developing dark fermentative biohydrogen production processes. The proposed pipeline might be considered as a blue-print for enhancing other bioprocesses that fundamentally face metabolic restrictions or kinetic limitations.
在自然微生物生态系统中，生物体的代谢多样性使社区成员之间能够相互作用，并使它们能够进行共生相互作用。就生物技术而言，人工微生物联合体工程用于提高生物过程的生产力和产量。然而，为了在工业规模上实现最高的生产力或效率，必须对定义明确的生态系统进行生理上的精心选择，以满足生态生物技术的需求。在这里，我们提出了一个人工微生物联合体设计和工程管道，用于开发黑暗发酵生物制氢过程。所提出的管道可以被认为是增强其他从根本上面临代谢限制或动力学限制的生物过程的蓝图。
