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使用微粉化脱细胞真皮基质填充剂治疗线状硬皮病(剑伤样硬皮病):一例报告

Treatment of Linear Morphea (en Coup de Sabre) with Micronized Acellular Dermal Matrix Filler: A Case Report.

作者信息

Kim Jemin, Kim Jihee, Lee Young In, Lee Ju Hee

机构信息

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, Seoul, Korea.

出版信息

Ann Dermatol. 2021 Aug;33(4):373-376. doi: 10.5021/ad.2021.33.4.373. Epub 2021 Jul 1.

Abstract

En coup de sabre variant of linear morphea (LM) is a rare sclerotic skin disorder characterized by disfiguring linear depression of the frontal or frontoparietal forehead. Current attempts for cosmetic correction of atrophic lesions must be preceded by an evaluation of disease activity of LM, either by a sufficient clinical assessment or histologic evidence. Corrective procedures including corrective surgery, autologous fat grafting, hyaluronic acid filler injections were performed with varying degrees of success; still, there is a need for treatment options with non-invasive and long-term maintenance effects. Herein we report the use of micronized acellular dermal matrix filler as a novel and successful treatment for the atrophic defect of LM in a 24-year-old female. Molecular characteristics of the micronized acellular dermal matrix filler give enhanced durability and prolonged volume consistency, which results in a long-term extracellular matrix remodeling effect.

摘要

线状硬皮病(LM)的军刀砍伤样变型是一种罕见的硬化性皮肤病,其特征为前额或额顶部出现毁容性线状凹陷。目前,在对萎缩性病变进行美容矫正之前,必须通过充分的临床评估或组织学证据来评估LM的疾病活动度。包括矫正手术、自体脂肪移植、透明质酸填充剂注射在内的矫正程序取得了不同程度的成功;然而,仍需要具有非侵入性和长期维持效果的治疗选择。在此,我们报告了使用微粉化脱细胞真皮基质填充剂成功治疗一名24岁女性LM萎缩性缺损的新案例。微粉化脱细胞真皮基质填充剂的分子特性赋予了其更高的耐久性和更长时间的体积稳定性,从而产生长期的细胞外基质重塑效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f439/8273327/fc27534b851a/ad-33-373-g001.jpg

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