Moloney J B, Hillery M, Fenton M
Research Foundation, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
Acta Ophthalmol (Copenh). 1987 Dec;65(6):731-4. doi: 10.1111/j.1755-3768.1987.tb07072.x.
A 19-year-old girl presenting with quinine amblyopia had serial electrophysiology studies over a 2 year period. Visually evoked responses and the electro-oculogram were abolished early. By 2 months the VER and visual acuity had returned to normal. The electroretinogram, initially mildly subnormal, became virtually abolished by 2 months. No recovery in cone function took place. Of the rods 50% regained function with normal latency by 1 year, but receptor sensitivity did not return to normal until 2 years after ingestion. The electro-oculogram also recovered slowly over a 2 year period. This pattern suggest that quinine exerts a direct toxic effect on the cells of the outer retina and pigment epithelium, as well as on the ganglion cells.
一名19岁的奎宁性弱视女孩在2年时间里接受了系列电生理研究。视觉诱发电位和眼电图早期消失。到2个月时，视觉诱发电位和视力恢复正常。视网膜电图最初轻度低于正常，到2个月时几乎消失。视锥细胞功能未恢复。50%的视杆细胞在1年时恢复功能且潜伏期正常，但直到摄入后2年受体敏感性才恢复正常。眼电图在2年时间里也缓慢恢复。这种模式表明奎宁对外层视网膜和色素上皮细胞以及神经节细胞有直接毒性作用。
