Association study of Catechol-O-Methyltransferase () rs4680 Val158Met gene polymorphism and suicide attempt in Mexican adolescents with major depressive disorder.

AIM

We analyzed the association between , , and genes and suicide attempt (SA) in Mexican adolescent patients with major depressive disorder (MDD).

METHODS

The sample included 197 adolescents (127 females and 70 males) with principal diagnosis of MDD. Among them, 63 patients had SA at least once and 134 had not SA. The mean age of patients with and without SA was 15±1.4 and 14±1.5years, respectively. We analyzed the genotype and allele distribution between patients with and without SA of (5HTTLPR/rs25531), (rs6275), (rs4680), and (uVNTR).

RESULTS

We did not find genotype or allele association between SA and (χ=0.67, =0.71; χ=0.07, =0.77, respectively), (χ=0.05, =0.97; χ=0.003, =0.95), and (females: χ=0.86, =0.64; χ=0, =1/males: χ=0.008, =0.92) genes. However, there were differences in genotype frequencies of /rs4680 between patients with SA and without SA (χ=11.17, =0.003). Also, we observed a high frequency of Met158 allele showing an increased risk of having presented at least one SA (χ=10.6, =0.001; OR=1.43; 95% CI, 1.17-1.74).

CONCLUSIONS

Our findings showed an association between low activity genotype and allele of Val158Met polymorphism of gene and SA in Mexican adolescents with MDD.