Huuhka Kaija, Anttila Sami, Huuhka Martti, Hietala Jarmo, Huhtala Heini, Mononen Nina, Lehtimäki Terho, Leinonen Esa
University of Tampere, Medical School, 33014 University of Tampere, Finland.
Neurosci Lett. 2008 Dec 19;448(1):79-83. doi: 10.1016/j.neulet.2008.10.015. Epub 2008 Oct 9.
Alterations in dopamine levels and dopamine receptors in brain are suggested to be associated with treatment response in electroconvulsive therapy (ECT). Dopamine 2 receptor gene (DRD2) polymorphism C957T (rs6277) and cathechol-o-methyltransferase (COMT) polymorphism Val158Met (rs4680) interaction was studied in 118 patients suffering from major depressive disorder (MDD) treated with ECT and 383 healthy controls. It was found that the combination of COMT Met allele and DRD2 T allele predicted more severe depression in those already affected but did not predict the risk of depression when compared to normal population. The genotype modified the response to ECT. The patients with TT genotype of D2 receptor gene C957T polymorphism combined with COMT gene polymorphism Met/Met genotype did not achieve remission as often as those with CC genotype of DRD2 C957T combined with COMT Val/Val genotype. Thus the interaction of these polymorphisms may be associated with response to ECT.
大脑中多巴胺水平和多巴胺受体的改变被认为与电休克治疗（ECT）的治疗反应有关。对118例接受ECT治疗的重度抑郁症（MDD）患者和383名健康对照者研究了多巴胺2受体基因（DRD2）多态性C957T（rs6277）和儿茶酚-O-甲基转移酶（COMT）多态性Val158Met（rs4680）的相互作用。研究发现，COMT Met等位基因和DRD2 T等位基因的组合在已患病者中预示着更严重的抑郁，但与正常人群相比，并未预示患抑郁症的风险。该基因型改变了对ECT的反应。D2受体基因C957T多态性的TT基因型与COMT基因多态性Met/Met基因型组合的患者与DRD2 C957T的CC基因型与COMT Val/Val基因型组合的患者相比，未那么频繁地实现缓解。因此，这些多态性的相互作用可能与对ECT的反应有关。
