Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dermatol Ther. 2021 Sep;34(5):e15083. doi: 10.1111/dth.15083. Epub 2021 Aug 7.
Seborrheic keratosis (SK) is a common benign skin epidermal lesion. Different treatment modalities have been proposed for this lesion. This study aimed to compare the efficacy and safety of electrodesiccation, cryotherapy, CO2 laser, and Er:YAG laser in the treatment of SK. The study was carried out on 30 patients each with four similar facial SKs. Each lesion was assigned to be treated with cryotherapy, electrodesiccation, CO2 laser, and Er:YAG laser in a random fashion. Therapeutic results were evaluated 8 weeks after the interventions through clinical and dermatoscopic assessment. Treatment improvement criteria for each lesion included the texture of the lesion, severity of the pigmentation, and an overall assessment of the healing. The severity of burning, pain, erythema, and the duration of the erythema after the procedures were documented. A survey of the patients' satisfaction with the treatments was also performed. In the assessment of overall lesion healing by two dermatologists, the improvement rate was significantly higher in the CO2, Er:YAG lasers and electrodesiccation group compared to the cryotherapy (p < 0.001). However, the CO2 and Er:YAG laser and the electrodesiccation groups showed no significant difference (p > 0.05). Moreover, no significant difference was observed in posttreatment pigmentation and texture between the groups (p > 0.05). The pain and burning severity after the interventions were negligible in all four groups. Prolonged erythema was not observed in any of the cases; however, the duration of erythema in the Er:YAG laser group was significantly longer (p < 0.001). Patient satisfaction in the cryotherapy group was significantly lower than the other three groups (p < 0.001). The efficacy of treatment and patient satisfaction rate is highly comparable between electrodesiccation, CO2 laser, and Er:YAG laser but significantly higher than cryotherapy.
脂溢性角化病（SK）是一种常见的良性皮肤表皮病变。针对这种病变已经提出了不同的治疗方法。本研究旨在比较电干燥、冷冻疗法、CO2 激光和 Er:YAG 激光治疗 SK 的疗效和安全性。该研究共纳入 30 名患者，每位患者有 4 处相似的面部 SK。随机将每个病变分配接受冷冻疗法、电干燥、CO2 激光和 Er:YAG 激光治疗。干预 8 周后通过临床和皮肤镜评估来评估治疗效果。治疗改善标准包括病变的质地、色素沉着的严重程度以及愈合的整体评估。记录了每个病变的灼烧、疼痛、红斑的严重程度以及治疗后的红斑持续时间。还对患者对治疗的满意度进行了调查。在两位皮肤科医生对整体病变愈合的评估中，CO2、Er:YAG 激光和电干燥组的改善率明显高于冷冻疗法组（p<0.001）。然而，CO2 和 Er:YAG 激光和电干燥组之间没有显著差异（p>0.05）。此外，各组之间治疗后的色素沉着和质地没有显著差异（p>0.05）。所有 4 组干预后的疼痛和灼烧严重程度均可以忽略不计。在任何情况下均未观察到延长的红斑，但是 Er:YAG 激光组的红斑持续时间明显更长（p<0.001）。冷冻疗法组患者的满意度明显低于其他三组（p<0.001）。电干燥、CO2 激光和 Er:YAG 激光的治疗效果和患者满意度非常相似，但明显高于冷冻疗法。
