Effect of enzyme inducer flumecinolum (Zixoryn) on aminophylline metabolism in rats.
作者信息
Szeitz A, Huszár E, Herjavecz I, Vértes K, Debreczeni L A
机构信息
Clinical Pharmacology and Pathophysiological Research Unit, National Korányi, Institute for TBC and Pulmonology, Budapest, Hungary.
出版信息
Acta Physiol Hung. 1987;70(2-3):317-21.
PMID:3434310
Abstract
The effect of the enzyme inducer flumecinolum, m-trifluoromethyl-alpha-ethylbenzhydrol (Zixoryn), on aminophylline metabolism was examined in rats. Aminophylline plasma levels were determined by HPLC. Aminophylline T1/2 was 2.85 hours (r = 0.9353) in the pretreated group and 3.75 hours (r = 0.9471) in the untreated control group. Flumecinolum was found to accelerate the elimination of aminophylline and the effect became significant 3.92 hours after the administration of aminophylline.
摘要
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