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鼻内镜改良黏膜瓣技术修复新生儿及婴儿先天性后鼻孔闭锁

[Nasal endoscopic modified mucosal flap technique for repair of congenital choanal atresia in newborns and infants].

作者信息

Wang P P, Tang L X, Yang X J, Zhang W, Xiao X, Han Y, Zhang J, Ge W T

机构信息

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing 100045, China.

出版信息

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Jul 7;56(7):713-718. doi: 10.3760/cma.j.cn115330-20200812-00668.

Abstract

To describe and evaluate the surgical effect and prognosis of nasal endoscopic modified mucosal flap technique for repair of congenital choanal atresia in newborns and infants. The clinical data of 38 newborns and infants with congenital choanal atresia who underwent nasal endoscopic surgery in Beijing Children's Hospital between January 2016 and May 2018 were retrospectively analysed, including 13 males and 25 females. The age ranged from 5 days to 3 years old at the time of operation (15 cases were newborns). The clinical data, imaging data, treatment effect and prognosis were collected. According to the different surgical methods, the patients were divided into the conventional operation group and the modified mucosal flap technique group. The designs of the modified mucosal flap technique were designed according to the type of congenital choanal atresia. The cross-over L-shaped flaps were performed in patients with unilateral atresia, and the mirrored L-shaped flaps were performed in patients with bilateral atresia. All the patients were followed up for 2-3 years, and the follow-up parameters included the times of operations, length of hospital stay, restenosis rate and incidence of complications. Study data was analyzed using SAS version 9.4 statistical software. Sixteen cases underwent conventional operation while 22 patients underwent modified mucosal flap technique under nasal endoscope. The lightest weight (2 200 g) and the youngest age (5 days) of the patients came from the modified mucosal flap technique group. Compared with the conventional operation group under nasal endoscope, the modified mucosal flap technique group had fewer times of operations (1.14±0.47 2.69±1.20, 5.552, 0.001), shorter hospital stay ((7.70±3.22) d (14.37±19.16) d, 2.960, 0.005), lower rate of postoperative restenosis (9.1% 43.8%, χ²=6.156, 0.013), and lower rate of the incidence of complications (13.6% 43.8%, χ²=5.955, 0.015), the differences were statistically significant. The nasal endoscopic modified mucosal flap technique is feasible for repairing congenital choanal atresia in newborns and infants, which can significantly reduce the incidence of postoperative restenosis and complications.

摘要

描述和评估鼻内镜改良黏膜瓣技术修复新生儿及婴幼儿先天性后鼻孔闭锁的手术效果及预后。回顾性分析2016年1月至2018年5月在北京儿童医院接受鼻内镜手术的38例先天性后鼻孔闭锁新生儿及婴幼儿的临床资料,其中男13例,女25例。手术时年龄5天至3岁(新生儿15例)。收集临床资料、影像学资料、治疗效果及预后情况。根据手术方法不同,将患者分为传统手术组和改良黏膜瓣技术组。改良黏膜瓣技术根据先天性后鼻孔闭锁类型设计。单侧闭锁患者采用交叉L形瓣,双侧闭锁患者采用镜像L形瓣。所有患者随访2至3年,随访指标包括手术次数、住院时间、再狭窄率及并发症发生率。采用SAS 9.4版统计软件分析研究数据。16例患者接受传统手术,22例患者在鼻内镜下采用改良黏膜瓣技术。改良黏膜瓣技术组患者体重最轻(2200g)、年龄最小(5天)。与鼻内镜下传统手术组相比,改良黏膜瓣技术组手术次数少(1.14±0.47比2.69±1.20,F=5.552,P=0.001)、住院时间短((7.70±3.22)天比(14.37±19.16)天,t=2.960,P=0.005)、术后再狭窄率低(9.1%比43.8%,χ²=6.156,P=0.013)、并发症发生率低(13.6%比43.8%,χ²=5.955,P=0.015),差异有统计学意义。鼻内镜改良黏膜瓣技术修复新生儿及婴幼儿先天性后鼻孔闭锁可行,可以显著降低术后再狭窄及并发症的发生率。

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