From the Department of Adult Hematology Blood and Marrow Transplant (Gassas), King Abdulaziz Medical City, National Guard Health Affairs; and from the Adult Hematology Blood and Marrow Transplant Unit (Absi, Alghamdi, Alsaeed, Alamoudi, Hemaidi, Alahmadi, Rajkhan, Khalil, Dadah, Higazi, Ahmed), Princess Noorah Oncology Center, Jeddah, Kingdom of Saudi Arabia.
Saudi Med J. 2021 Aug;42(8):847-852. doi: 10.15537/smj.2021.42.8.20210236.
To assess local epidemiology and risk factors for bacterial, fungal, and viral infections among the autologous bone marrow transplant population.
This study is a retrospective correlational cohort design comprising 150 adult patients who underwent autologous transplants at Princess Noorah Oncology Center, Jeddah, Saudi Arabia between 2014 and 2020.
The study findings indicate that bacterial infection prevalence differed significantly across the different disease status pre-salvage as patients with the relapsed disease were more likely to have bacterial infections. The median of engraftment days differed significantly between those who had a bacterial infection and those who did not. Interestingly, previous pneumonia infection had a positive relationship with the number of hospital stays.
Bacterial infections are the dominant type of infection among the autologous patient population. The research reflects authentic practice and reports unique characteristics of autologous transplant patients in terms of the prevalence and types of infection these patients experience.
评估自体骨髓移植人群中细菌、真菌和病毒感染的局部流行病学和危险因素。
本研究是一项回顾性相关性队列设计，包括 2014 年至 2020 年间在沙特阿拉伯吉达的努拉公主肿瘤中心接受自体移植的 150 名成年患者。
研究结果表明，不同疾病状态下（挽救前）细菌感染的流行率存在显著差异，复发疾病患者更容易发生细菌感染。发生细菌感染和未发生细菌感染的患者的植入天数中位数存在显著差异。有趣的是，既往肺炎感染与住院次数呈正相关。
细菌感染是自体患者人群中主要的感染类型。该研究反映了真实实践，并报告了自体移植患者在感染的流行率和类型方面的独特特征。
