From the College of Medicine (Al Sheikh) Assistant Professor, King Saud Bin Abdulaziz University for Health Sciences; from the Division of Orthopedics, Department of Surgery, (Al Sheikh, AlHandi, Ateeq, AlAqeely) King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the College of Medicine (Bin Dohaim), King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabiaand from King Abdullah International Medical Research Center, Riyadh City, Saudi Arabia.
Saudi Med J. 2021 Aug;42(8):908-912. doi: 10.15537/smj.2021.42.8.20210332.
To measure the effectiveness of tranexamic acid (TXA); in total joint arthroplastyin terms of reducing post-operative blood loss.
A retrospective cohort study in which patients who had underwent total hip arthroplasty (THA) and TKA between 2010-2018 in a single tertiary center. Those had received TXA (group 1) and those who had received no-TXA (group 2) were evaluated. Unpaired student's t-test was used to compare TXA and no-TXA groups for continuous variables and Chi-square test was used for categorical variables. A value<0.05 was considered significant.
A total of 385 patients were included, 180 patients received TXA, and 205 patients received no-TXA. Post-operative blood loss was significantly less in TXA group (13.41±9.51, <0.001). Total drainage output was significantly lower in TXA group compared to no-TXA (373.98±246.12 vs. 487.11±307.13 mL, <0.001). Blood transfusion units were significantly less in TXA group than in the control group (20 units; 11.1% vs. 50 units; 24.4%, <0.001).
Tranexamic acid use in TKA and THA is effective in reducing post-operative blood loss in terms of drop in Hg level, total drainage output and blood transfusion rate.
评估氨甲环酸（TXA）在全髋关节置换术（THA）和全膝关节置换术（TKA）中减少术后失血的效果。
这是一项回顾性队列研究，纳入了 2010 年至 2018 年期间在一家三级中心接受全髋关节置换术（THA）和全膝关节置换术（TKA）的患者。将接受 TXA（组 1）和未接受 TXA（组 2）的患者进行评估。连续变量采用独立样本 t 检验进行比较，分类变量采用卡方检验进行比较。P 值<0.05 为差异有统计学意义。
共纳入 385 例患者，其中 180 例患者接受 TXA，205 例患者未接受 TXA。TXA 组术后失血量明显少于对照组（13.41±9.51，<0.001）。TXA 组总引流量明显少于对照组（373.98±246.12 vs. 487.11±307.13 mL，<0.001）。TXA 组输血单位数明显少于对照组（20 单位；11.1% vs. 50 单位；24.4%，<0.001）。
TKA 和 THA 中使用氨甲环酸可有效降低术后失血量，表现为血红蛋白下降、总引流量和输血率降低。
