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[药物抵抗性雷诺现象患者的交感神经切断术]

[Sympathicotomy in patients with drug resistant Raynaud's phenomenon].

作者信息

van Roon Anniek M, Eman Abdulle Amaal, Zhang Dan, Stel Alja J, Kuijpers Michiel, Mulder D J

机构信息

Universitair Medisch Centrum Groningen, afd. Reumatologie en Klinische Immunologie, Groningen.

Contact: Anniek M. van Roon (

出版信息

Ned Tijdschr Geneeskd. 2021 Jun 21;165:D5630.

Abstract

Raynaud's phenomenon (RP) is a disorder of the microvasculature which causes poor blood flow to the digits. This disorder is common in young females and may be associated with several underlying connective tissue diseases including systemic sclerosis. Although RP may have a tremendous impact on quality of life, treatment options are limited. Conventional medical treatment mainly consists of vasodilatory drugs, which are not effective in all patients and may induce undesired side effects. The current clinical lesson describes three patients with severe RP who all underwent a novel, minimally invasive, single-port thoracoscopic sympathicotomy (SPTS). Although this procedure seems promising in patients with treatment-resistant RP, as shown with patients A and B, future research has yet to show what the long-term effects are.

摘要

雷诺现象(RP)是一种微血管疾病,会导致手指血液流动不畅。这种疾病在年轻女性中很常见,可能与包括系统性硬化症在内的几种潜在结缔组织疾病有关。尽管雷诺现象可能对生活质量产生巨大影响,但治疗选择有限。传统医学治疗主要包括血管扩张药物,这些药物并非对所有患者都有效,且可能会引起不良副作用。当前的临床病例描述了三名严重雷诺现象患者,他们均接受了一种新型的、微创的单孔胸腔镜交感神经切断术(SPTS)。尽管正如患者A和B所示,该手术在治疗抵抗性雷诺现象患者中似乎很有前景,但未来的研究仍需揭示其长期效果如何。

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