1例雷特综合征患者大脑中抗坏血酸和谷胱甘肽浓度降低：一项尸检脑研究

Reduced concentrations of ascorbic acid and glutathione in a single case of Rett syndrome: a postmortem brain study.

作者信息

Sofić E, Riederer P, Killian W, Rett A

机构信息

Department of Psychiatry, University of Würzburg, FRG.

出版信息

Brain Dev. 1987;9(5):529-31. doi: 10.1016/s0387-7604(87)80079-7.

DOI:10.1016/s0387-7604(87)80079-7

PMID:3434732

Abstract

Preliminary data of a postmortem brain study in a single case with Rett syndrome compared to a single control case showed a severe reduction of ascorbic acid and reduced glutathione in most brain regions studied. These findings suggest a secondary disturbance of ascorbic acid and glutathione metabolism in the Rett syndrome.

摘要

一项针对一名雷特综合征患者与一名对照个体的尸检脑研究的初步数据显示，在所研究的大多数脑区中，抗坏血酸和还原型谷胱甘肽严重减少。这些发现表明雷特综合征中抗坏血酸和谷胱甘肽代谢存在继发性紊乱。