Duca Maria, Gillingham Dennis, Olsen Christian Adam, Sbardella Gianluca, Skaanderup Philip R, van der Stelt Mario, Vauzeilles Boris, Vázquez Olalla, Auberson Yves P
Université Côte d'Azur - CNRS, Institut de Chimie de Nice (ICN), Parc Valrose, 06100, Nice, France.
Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056, Basel, Switzerland.
Chembiochem. 2021 Oct 1;22(19):2823-2825. doi: 10.1002/cbic.202100319. Epub 2021 Aug 4.
The European Federation for Medicinal chemistry and Chemical biology (EFMC) is a federation of learned societies. It groups organizations of European scientists working in a dynamic field spanning chemical biology and medicinal chemistry. New ideas, tools, and technologies emerging from a wide array of scientific disciplines continuously energize this rapidly evolving area. Medicinal chemistry is the design, synthesis, and optimization of biologically active molecules aimed at discovering new drug candidates - a mission that in many ways overlaps with the scope of chemical biology. Chemical biology is by now a mature field of science for which a more precise definition of what it encompasses, in the frame of EFMC, is timely. This article discusses chemical biology as currently understood by EFMC, including all activities dealing with the design and synthesis of biologically active chemical tools and their use to probe, characterize, or influence biological systems.
欧洲药物化学与化学生物学联合会（EFMC）是一个学术团体联盟。它汇聚了在化学生物学和药物化学这一充满活力的领域工作的欧洲科学家组织。来自广泛科学学科的新思想、工具和技术不断为这个快速发展的领域注入活力。药物化学是针对发现新的候选药物进行生物活性分子的设计、合成和优化——这一使命在许多方面与化学生物学的范畴相重叠。如今，化学生物学已是一个成熟的科学领域，在EFMC的框架内，及时对其涵盖内容给出更精确的定义很有必要。本文讨论了EFMC目前所理解的化学生物学，包括所有涉及生物活性化学工具的设计与合成以及将其用于探测、表征或影响生物系统的活动。
