Grant Jonathan J, McDade Erin J, Zobell Jeffery T, Young David C
Department of Outpatient Pharmacy-Specialty Services, The John's Hopkins Hospital, Baltimore, Maryland, USA.
Pharmacy Department, Texas Children's Hospital, Houston, Texas, USA.
Pediatr Pulmonol. 2022 Feb;57 Suppl 1:S17-S39. doi: 10.1002/ppul.25613. Epub 2021 Aug 11.
Care for people with cystic fibrosis (PWCF) is highly complex and requires a multidisciplinary approach where the pharmacist plays a vital role. The purpose of this manuscript is to serve as a guideline for pharmacists and pharmacy technicians who provide care for PWCF by providing background and current recommendations for the use of cystic fibrosis (CF)-specific medications in both the acute and ambulatory care settings. The article explores current literature surrounding the role of pharmacists and pharmacy technicians, proven pharmacy models to emulate, and pharmacokinetic idiosyncrasies unique to the CF population while also identifying areas of future research. Clinical recommendations for the use of CF-specific medications are broken down by organ system including mechanism of action, adverse events, dosages, and monitoring parameters. The article also includes quick reference tables essential to the acute and chronic medication therapy management of PWCF.
对囊性纤维化患者（PWCF）的护理非常复杂，需要多学科方法，药剂师在其中发挥着至关重要的作用。本手稿的目的是为在急性和门诊护理环境中为PWCF提供护理的药剂师和药房技术员提供指导方针，通过提供使用囊性纤维化（CF）特异性药物的背景和当前建议。本文探讨了围绕药剂师和药房技术员角色的当前文献、可效仿的成熟药房模式以及CF人群特有的药代动力学特性，同时还确定了未来研究的领域。使用CF特异性药物的临床建议按器官系统进行分解，包括作用机制、不良事件、剂量和监测参数。本文还包括对PWCF急性和慢性药物治疗管理至关重要的快速参考表。
