• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

作者信息

Tirosh Amir, Tuncman Gurol, Calay Ediz S, Rathaus Moran, Ron Idit, Tirosh Amit, Yalcin Abdullah, Lee Yankun G, Livne Rinat, Ron Sophie, Minsky Neri, Arruda Ana Paula, Hotamisligil Gökhan S

出版信息

Cell Metab. 2021 Aug 3;33(8):1716. doi: 10.1016/j.cmet.2021.07.005.

DOI:10.1016/j.cmet.2021.07.005
PMID:34348100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8388259/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92c5/8388259/7011a18b67ab/nihms-1726671-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92c5/8388259/923348fca413/nihms-1726671-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92c5/8388259/7011a18b67ab/nihms-1726671-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92c5/8388259/923348fca413/nihms-1726671-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92c5/8388259/7011a18b67ab/nihms-1726671-f0002.jpg

相似文献

1
Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.肥胖中肝脏内质网应激的细胞间传递破坏全身代谢。
Cell Metab. 2021 Aug 3;33(8):1716. doi: 10.1016/j.cmet.2021.07.005.
2
High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress.高饱和脂肪饮食诱导的肥胖通过内质网应激引起肝脏白细胞介素 6 抵抗。
J Lipid Res. 2019 Jul;60(7):1236-1249. doi: 10.1194/jlr.M092510. Epub 2019 May 13.
3
Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice.羟基酪醇通过调节内质网应激改善胰岛素抵抗，预防饮食诱导肥胖小鼠的肝脂肪变性。
J Nutr Biochem. 2018 Jul;57:180-188. doi: 10.1016/j.jnutbio.2018.03.018. Epub 2018 Apr 2.
4
Cudrania tricuspidata water extract improved obesity-induced hepatic insulin resistance in db/db mice by suppressing ER stress and inflammation.柘树水提取物通过抑制内质网应激和炎症改善db/db小鼠肥胖诱导的肝脏胰岛素抵抗。
Food Nutr Res. 2015 Oct 26;59:29165. doi: 10.3402/fnr.v59.29165. eCollection 2015.
5
NK cells induce hepatic ER stress to promote insulin resistance in obesity through osteopontin production.自然杀伤细胞通过产生骨桥蛋白诱导肝内质网应激，从而促进肥胖中的胰岛素抵抗。
J Leukoc Biol. 2020 Apr;107(4):589-596. doi: 10.1002/JLB.3MA1119-173R. Epub 2019 Dec 12.
6
Endoplasmic Reticulum Stress in Mice Increases Hepatic Expression of Genes Carrying a Premature Termination Codon via a Nutritional Status-Independent GRP78-Dependent Mechanism.小鼠内质网应激通过一种不依赖营养状态的GRP78依赖性机制增加携带提前终止密码子的基因的肝脏表达。
J Cell Biochem. 2017 Nov;118(11):3810-3824. doi: 10.1002/jcb.26031. Epub 2017 Apr 25.
7
Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress.成纤维细胞生长因子21参与内质网应激适应并减轻肥胖诱导的肝脏代谢应激。
Diabetologia. 2015 Apr;58(4):809-18. doi: 10.1007/s00125-014-3475-6. Epub 2014 Dec 24.
8
Endoplasmic reticulum stress, obesity and diabetes.内质网应激、肥胖和糖尿病。
Trends Mol Med. 2012 Jan;18(1):59-68. doi: 10.1016/j.molmed.2011.07.010. Epub 2011 Aug 31.
9
Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress.ZIP14 介导的肝脏锌转运对于内质网应激适应是必需的。
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5805-E5814. doi: 10.1073/pnas.1704012114. Epub 2017 Jul 3.
10
Unfolded Protein Response Sensors in Hepatic Lipid Metabolism and Nonalcoholic Fatty Liver Disease. unfolded 蛋白反应传感器在肝脂代谢和非酒精性脂肪性肝病中的作用。
Semin Liver Dis. 2018 Nov;38(4):320-332. doi: 10.1055/s-0038-1670677. Epub 2018 Oct 24.

引用本文的文献

1
Insulin resistance in type 2 diabetes mellitus.2型糖尿病中的胰岛素抵抗。
Nat Rev Endocrinol. 2025 Apr 17. doi: 10.1038/s41574-025-01114-y.
2
Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators.星形胶质细胞和神经元内质网应激信号传递及其介质的初步探索
Mol Med Rep. 2025 Jun;31(6). doi: 10.3892/mmr.2025.13532. Epub 2025 Apr 17.
3
Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance.在伴有胰岛素抵抗的多囊卵巢综合征患者中，肥胖与性激素结合球蛋白水平相关，而与血脂谱无关。
BMC Endocr Disord. 2024 Nov 25;24(1):254. doi: 10.1186/s12902-024-01789-w.
4
Multiple unfolded protein response pathways cooperate to link cytosolic dsDNA release to stimulator of interferon gene activation.多种未折叠蛋白反应途径协同作用将细胞质双链 DNA 释放与干扰素基因激活刺激物联系起来。
Front Immunol. 2024 Jul 19;15:1358462. doi: 10.3389/fimmu.2024.1358462. eCollection 2024.
5
18-α-glycyrrhetinic acid alleviates oxidative damage in periodontal tissue by modulating the interaction of Cx43 and JNK/NF-κB pathways.18-α-甘草次酸通过调节Cx43与JNK/NF-κB信号通路的相互作用减轻牙周组织的氧化损伤。
Front Pharmacol. 2023 Jul 19;14:1221053. doi: 10.3389/fphar.2023.1221053. eCollection 2023.
6
Inhibition of MiR-106b-5p mediated by exosomes mitigates acute kidney injury by modulating transmissible endoplasmic reticulum stress and M1 macrophage polarization.外泌体介导的MiR-106b-5p抑制通过调节可传播的内质网应激和M1巨噬细胞极化减轻急性肾损伤。
J Cell Mol Med. 2023 Oct;27(19):2876-2889. doi: 10.1111/jcmm.17848. Epub 2023 Jul 20.
7
ER-stress-induced secretion of circulating glucose-regulated protein 78kDa (GRP78) ameliorates pulmonary artery smooth muscle cell remodelling.内质网应激诱导的循环葡萄糖调节蛋白 78kDa（GRP78）分泌可改善肺动脉平滑肌细胞重塑。
Cell Stress Chaperones. 2022 Sep;27(5):561-572. doi: 10.1007/s12192-022-01292-y. Epub 2022 Aug 27.
8
Brain Microvascular Pericytes-More than Bystanders in Breast Cancer Brain Metastasis.脑微血管周细胞——乳腺癌脑转移的不仅仅是旁观者。
Cells. 2022 Apr 8;11(8):1263. doi: 10.3390/cells11081263.
9
Gap Junction-Dependent and -Independent Functions of Connexin43 in Biology.生物学中连接蛋白43的间隙连接依赖性和非依赖性功能
Biology (Basel). 2022 Feb 11;11(2):283. doi: 10.3390/biology11020283.
10
An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesis.不只是一个受害者的共犯：β 细胞内质网应激对 1 型糖尿病发病机制的影响。
Mol Metab. 2021 Dec;54:101365. doi: 10.1016/j.molmet.2021.101365. Epub 2021 Oct 30.