Eiben B, Leipoldt M, Rammelsberg O, Krause W, Engel W
Institut of Human Genetics, University of Göttingen, Fed. Rep. Germany.
Andrologia. 1987 Nov-Dec;19(6):684-7. doi: 10.1111/j.1439-0272.1987.tb01929.x.
Chromosomal analysis was performed on 109 males with teratozoospermia. Four cases of anomaly were found, including three cases of mosaic Klinefelter's syndrome and one balanced autosomal translocation. Among chromosomal heteromorphisms, 9qh+ was found in 25% of the patients. The fraction of malformed spermatozoa in the semen of the 9qh+ group is significantly higher than in the chromosomally normal group. It is speculated that heterochromatic variants like 9qh+ could be one of several unknown factors disturbing normal gametogenesis.
对109名患有畸形精子症的男性进行了染色体分析。发现4例异常，包括3例嵌合型克兰费尔特综合征和1例常染色体平衡易位。在染色体异态性中，25%的患者发现有9qh+。9qh+组精液中畸形精子的比例显著高于染色体正常组。据推测，像9qh+这样的异染色质变体可能是干扰正常配子发生的几个未知因素之一。
