Department of Internal Medicine, University of Alabama at Birmingham (UAB), 1720 2nd Avenue S, BDB 327, Birmingham, AL, 35233, USA.
Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
BMC Cardiovasc Disord. 2021 Aug 4;21(1):375. doi: 10.1186/s12872-021-02183-3.
Half of U.S. adults have received at least one dose of the COVID-19 vaccines produced by either Pfizer, Moderna, or Johnson and Johnson, which represents a major milestone in the ongoing pandemic. Given the emergency use authorizations for these vaccines, their side effects and safety were assessed over a compressed time period. Hence, ongoing monitoring for vaccine-related adverse events is imperative for a full understanding and delineation of their safety profile.
An 22-year-old Caucasian male presented to our hospital center complaining of pleuritic chest pain. Six months prior he had a mild case of COVID-19, but was otherwise healthy. He had received his first dose of the Moderna vaccine three days prior to developing symptoms. Laboratory analysis revealed a markedly elevated troponin and multiple imaging modalities during his hospitalization found evidence of wall motion abnormalities consistent with a diagnosis of perimyocarditis. He was started on aspirin and colchicine with marked improvement of his symptoms prior to discharge.
We present a case of perimyocarditis that was temporally related to COVID-19 mRNA vaccination in an young male with prior COVID-19 infection but otherwise healthy. Our case report highlights an albeit rare but important adverse event for clinicians to be aware of. It also suggests a possible mechanism for the development of myocardial injury in our patient.
目前，美国已有一半成年人至少接种了一剂辉瑞、莫德纳或强生公司生产的新冠疫苗，这标志着这场持续大流行中的一个重要里程碑。鉴于这些疫苗的紧急使用授权，其副作用和安全性是在压缩的时间内进行评估的。因此，为了全面了解和明确其安全性，持续监测与疫苗相关的不良事件至关重要。
一名 22 岁的白人男性因胸痛来到我们医院中心就诊。他在六个月前曾患有轻度新冠肺炎，但除此之外身体健康。他在出现症状前三天接种了第一剂 Moderna 疫苗。实验室分析显示肌钙蛋白显著升高，住院期间的多种成像方式发现了与心肌炎一致的壁运动异常的证据。他开始服用阿司匹林和秋水仙碱，在出院前症状明显改善。
我们报告了一例心肌炎病例，该病例与一名年轻男性先前的 COVID-19 感染有关，但除此之外身体健康，与 COVID-19 mRNA 疫苗接种在时间上有关。我们的病例报告强调了一种罕见但重要的不良事件，临床医生需要对此有所了解。它还提示了我们患者心肌损伤发展的一种可能机制。
