Department of Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China.
Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital/Children's Hospital, Harvard Medical School, Boston, MA, United States.
Front Immunol. 2021 Jul 19;12:709178. doi: 10.3389/fimmu.2021.709178. eCollection 2021.
Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome expression level of cells with high-throughput from the single cell level, fully show the heterogeneity of cells, and provide a new way for the study of multicellular biological heterogeneity. Synovitis is the pathological basis of rheumatoid arthritis (RA). Synovial fibroblasts (SFs) and synovial macrophages are the core target cells of RA, which results in the destruction of articular cartilage, as well as bone. Recent scRNA-seq technology has made breakthroughs in the differentiation and development of two types of synovial cells, identification of subsets, functional analysis, and new therapeutic targets, which will bring remarkable changes in RA treatment.
单细胞 RNA 测序（scRNA-seq）技术可从单细胞水平高通量分析细胞的转录组表达水平，充分展示细胞的异质性，并为研究多细胞生物异质性提供新途径。滑膜炎是类风湿关节炎（RA）的病理基础。滑膜成纤维细胞（SFs）和滑膜巨噬细胞是 RA 的核心靶细胞，导致关节软骨和骨破坏。最近的 scRNA-seq 技术在两种滑膜细胞的分化和发育、亚群鉴定、功能分析和新的治疗靶点方面取得了突破，这将给 RA 的治疗带来显著变化。
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