Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Department of Pathophysiology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.
Front Immunol. 2021 Jul 19;12:713294. doi: 10.3389/fimmu.2021.713294. eCollection 2021.
The development and differentiation of T cells represents a long and highly coordinated, yet flexible at some points, pathway, along which the sequential and dynamic expressions of different transcriptional factors play prominent roles at multiple steps. The large ZBTB family comprises a diverse group of transcriptional factors, and many of them have emerged as critical factors that regulate the lineage commitment, differentiation and effector function of hematopoietic-derived cells as well as a variety of other developmental events. Within the T-cell lineage, several ZBTB proteins, including ZBTB1, ZBTB17, ZBTB7B (THPOK) and BCL6 (ZBTB27), mainly regulate the development and/or differentiation of conventional CD4/CD8 αβ T cells, whereas ZBTB16 (PLZF) is essential for the development and function of innate-like unconventional δ T & invariant NKT cells. Given the critical role of T cells in host defenses against infections/tumors and in the pathogenesis of many inflammatory disorders, we herein summarize the roles of fourteen ZBTB family members in the development, differentiation and effector function of both conventional and unconventional T cells as well as the underlying molecular mechanisms.
T 细胞的发育和分化代表了一个漫长而高度协调的过程，但在某些点上也具有一定的灵活性，在此过程中，不同转录因子的顺序和动态表达在多个步骤中发挥着突出的作用。庞大的 ZBTB 家族包含了一组多样化的转录因子，其中许多因子已成为调节造血细胞谱系定向、分化和效应功能以及多种其他发育事件的关键因素。在 T 细胞谱系中，包括 ZBTB1、ZBTB17、ZBTB7B（THPOK）和 BCL6（ZBTB27）在内的几种 ZBTB 蛋白，主要调节常规 CD4/CD8αβ T 细胞的发育和/或分化，而 ZBTB16（PLZF）则对先天样非常规 δ T 和不变自然杀伤 T 细胞的发育和功能至关重要。鉴于 T 细胞在宿主抗感染/抗肿瘤防御以及许多炎症性疾病发病机制中的关键作用，我们在此总结了十四种 ZBTB 家族成员在常规和非常规 T 细胞的发育、分化和效应功能中的作用及其潜在的分子机制。
