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将大剂量药物应用于口腔鳞状细胞癌不同部位的间隔器:技术说明与回顾性病例系列

Spacers with boluses applied to various sites of oral squamous cell carcinoma: Technical note and retrospective case series.

作者信息

Yoshizawa Kunio, Aoki Shinichi, Marino Kan, Matsuda Masaki, Moroi Akinori, Ueki Koichiro

机构信息

Department of Oral Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.

Department of Radiology, School of Medicine, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.

出版信息

Mol Clin Oncol. 2021 Sep;15(3):187. doi: 10.3892/mco.2021.2349. Epub 2021 Jul 13.

Abstract

The present report describes a case series in which spacers with boluses were used at various sites in the oral cavity to enhance the therapeutic effect of radiation therapy in oral squamous cell carcinoma. In radiotherapy, the surface dose is reduced due to the build-up region of X-rays. In the present study, a bolus was used to complement the build-up region and increase the surface dose effect. A total of 7 patients with oral cancer from a primary care hospital underwent radiation therapy using spacers and added boluses to improve the surface dose effect. The spacer was made from a plastic splint and the bolus was connected to the splint with a quick self-curing resin. There were no complaints of pain or adverse events from the patients while wearing the intraoral splint. A total of 2 of the 7 patients were subsequently confirmed as having progressed disease, and the remaining 5 are currently being managed following a complete response to treatment. The spacers used at various sites of oral squamous cell carcinoma were safe and effective and did not cause any severe adverse effects.

摘要

本报告描述了一个病例系列,其中在口腔的不同部位使用带有推注剂的间隔物来增强口腔鳞状细胞癌放射治疗的效果。在放射治疗中,由于X射线的建成区,表面剂量会降低。在本研究中,使用推注剂来补充建成区并增加表面剂量效应。一家基层医院的7例口腔癌患者接受了使用间隔物并添加推注剂的放射治疗,以改善表面剂量效应。间隔物由塑料夹板制成,推注剂通过快速自固化树脂与夹板相连。患者佩戴口内夹板时未出现疼痛或不良事件的主诉。7例患者中有2例随后被证实疾病进展,其余5例目前在对治疗完全缓解后正在接受管理。在口腔鳞状细胞癌的不同部位使用的间隔物安全有效,未引起任何严重不良反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ce/8327078/693d2b2ce8ff/mco-15-03-02349-g00.jpg

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