Department of Health-Business Administration, Fooyin University, Kaohsiung, Taiwan.
Division of Medical Statistics and Bioinformatics, Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Elife. 2021 Aug 5;10:e63954. doi: 10.7554/eLife.63954.
Methadone maintenance treatment (MMT) can alleviate opioid dependence. However, MMT possibly increases the risk of motor vehicle collisions. The current study investigated preliminary estimation of motor vehicle collision incidence rates. Furthermore, in this population-based retrospective cohort study with frequency-matched controls, opiate adults receiving MMT (cases) and those not receiving MMT (controls) were identified at a 1:2 ratio by linking data from several nationwide administrative registry databases. From 2009 to 2016, the crude incidence rate of motor vehicle collisions was the lowest in the general adult population, followed by that in opiate adults, and it was the highest in adults receiving MMT. The incidence rates of motor vehicle collisions were significantly higher in opiate users receiving MMT than in those not receiving MMT. Kaplan-Meier curves of the incidence of motor vehicle collisions differed significantly between groups, with a significant increased risk during the first 90 days of follow-up. In conclusion, drivers receiving MMT have higher motor vehicle collision risk than those not receiving MMT in opiate users, and it is worthy of noticing road safety in such drivers, particularly during the first 90 days of MMT.
美沙酮维持治疗（MMT）可以缓解阿片类药物依赖。然而，MMT 可能会增加发生机动车碰撞的风险。本研究旨在初步评估机动车碰撞发生率。在这项基于人群的回顾性队列研究中，采用频率匹配对照，通过链接来自几个全国性行政登记数据库的数据，按照 1:2 的比例确定接受 MMT（病例组）和未接受 MMT（对照组）的阿片类药物使用者。2009 年至 2016 年，机动车碰撞的粗发生率在普通成年人群中最低，其次是阿片类药物使用者，而接受 MMT 的成年人发生率最高。与未接受 MMT 的患者相比，接受 MMT 的阿片类药物使用者发生机动车碰撞的发生率显著更高。两组之间的机动车碰撞发生率的 Kaplan-Meier 曲线差异显著，在随访的前 90 天内风险显著增加。总之，与未接受 MMT 的患者相比，接受 MMT 的阿片类药物使用者中的驾驶员发生机动车碰撞的风险更高，因此在这些驾驶员中，特别是在 MMT 的前 90 天内，值得关注道路安全。
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