Wellman P J, Miller J
Department of Psychology, Texas A&M University, College Station 77843.
Appetite. 1987 Dec;9(3):231-6. doi: 10.1016/s0195-6663(87)80016-8.
The purpose of the present study was to compare the actions of the anorexigen phenylpropanolamine (PPA) on chronic feeding and body weight in lean and in genetically obese mice. Adult (8-week-old) female C57BL/6J ob/ob mice and female +/? lean control mice were treated (i.p.) twice daily (at 0800 hrs and 2000 hrs) for 21 days with either 0.9% saline or with 10 or 20 mg/kg PPA. Analyses of cumulative 72-hour food intake revealed that PPA induced significant and dose-dependent anorexia in ob/ob mice but that PPA was without significant anorectic effect in lean mice. PPA dose levels of 10 mg/kg and 20 mg/kg reduced food intake in ob/ob mice by 14 and 21%, but reduced food intake in lean mice by only 3 and 6%, respectively. Analyses of body weight, however, did not reveal significant changes in body weight induced by either PPA dose in ob/ob or lean mice. The enhanced anorexic effects induced by PPA and other adrenergic agents in the ob/ob mouse are discussed.
本研究的目的是比较厌食剂苯丙醇胺（PPA）对瘦小鼠和遗传性肥胖小鼠的慢性摄食及体重的作用。成年（8周龄）雌性C57BL/6J ob/ob小鼠和雌性+/？瘦对照小鼠每天两次（上午8点和晚上8点）腹腔注射0.9%生理盐水或10或20mg/kg PPA，持续21天。对72小时累积食物摄入量的分析表明，PPA在ob/ob小鼠中诱导了显著的、剂量依赖性的厌食，但在瘦小鼠中没有显著的厌食作用。10mg/kg和20mg/kg剂量的PPA使ob/ob小鼠的食物摄入量分别减少了14%和21%，但使瘦小鼠的食物摄入量仅分别减少了3%和6%。然而，对体重的分析并未显示PPA剂量在ob/ob或瘦小鼠中引起体重的显著变化。文中讨论了PPA和其他肾上腺素能药物在ob/ob小鼠中诱导的增强的厌食作用。
