新生儿外周化学感受器的产后敏感性
Postnatal sensitivity of the peripheral chemoreceptors in newborn infants.
作者信息
Hertzberg T, Lagercrantz H
机构信息
Nobel Institute for Neurophysiology, Karolinska Institute, Stockholm, Sweden.
出版信息
Arch Dis Child. 1987 Dec;62(12):1238-41. doi: 10.1136/adc.62.12.1238.
Abstract
The peripheral chemoreflex was tested in healthy term infants by measuring the ventilatory response to 100% oxygen over 30 seconds. Minute ventilation did not change when studied two to six hours after birth. By contrast, at 2-6 days of age a mean decrease of 9.8% was noted, the difference between the groups being highly significant. There were no significant changes in respiratory rate. It is concluded that the chemoreflex is less active immediately after birth than it is a few days later, possibly due to a resetting of the sensitivity of the peripheral chemoreceptors from the fetal state, with its relatively low arterial oxygen tension to the higher postnatal concentrations.
摘要
通过测量足月健康婴儿在30秒内对100%氧气的通气反应来测试外周化学反射。出生后两到六小时进行研究时，分钟通气量没有变化。相比之下，在2 - 6日龄时，平均下降了9.8%，两组之间的差异非常显著。呼吸频率没有显著变化。得出的结论是，出生后即刻化学反射比几天后的活性低，这可能是由于外周化学感受器的敏感性从胎儿状态（其动脉血氧张力相对较低）重新调整为出生后较高的浓度所致。
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