血小板在肝移植中的潜在作用：再生与癌症复发
Possible roles of platelets in liver transplantation: regeneration and cancer recurrence.
作者信息
Han Sangbin
机构信息
Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
Anesth Pain Med (Seoul). 2021 Jul;16(3):225-231. doi: 10.17085/apm.21063. Epub 2021 Jul 22.
Abstract
When tissue injury results in breakage, platelets are not only involved in plug formation and wound sealing, but they also play an important role throughout the tissue recovery process. Specifically, platelets accumulate at the site of injury and release a large number of biologically active mediators at injury sites, which initiate or modulate damaged tissue regeneration. Moreover, extensive experimental evidence has elucidated the involvement of platelets in tumor growth and metastasis. As such, this mini-review aimed to highlight the relatively lesser known functions of platelets.
摘要
当组织损伤导致破裂时，血小板不仅参与血栓形成和伤口愈合，而且在整个组织恢复过程中也发挥着重要作用。具体而言，血小板在损伤部位聚集，并在损伤部位释放大量生物活性介质，这些介质启动或调节受损组织的再生。此外，大量实验证据表明血小板参与肿瘤生长和转移。因此，本综述旨在突出血小板相对鲜为人知的功能。
相似文献
1
Possible roles of platelets in liver transplantation: regeneration and cancer recurrence.血小板在肝移植中的潜在作用：再生与癌症复发
Anesth Pain Med (Seoul). 2021 Jul;16(3):225-231. doi: 10.17085/apm.21063. Epub 2021 Jul 22.
2
Cooperation of liver cells in health and disease.健康与疾病状态下肝细胞的协作。
Adv Anat Embryol Cell Biol. 2001;161:III-XIII, 1-151. doi: 10.1007/978-3-642-56553-3.
3
Role of platelets in chronic liver disease and acute liver injury.血小板在慢性肝病和急性肝损伤中的作用。
Hepatol Res. 2014 Feb;44(2):165-72. doi: 10.1111/hepr.12205. Epub 2013 Aug 27.
4
Platelets in liver transplantation: friend or foe?肝移植中的血小板：是友还是敌？
Liver Transpl. 2008 Jul;14(7):923-31. doi: 10.1002/lt.21510.
5
A focus on the role of platelets in liver regeneration: Do platelet-endothelial cell interactions initiate the regenerative process?关注血小板在肝再生中的作用：血小板-内皮细胞相互作用是否启动了再生过程？
J Hepatol. 2015 Nov;63(5):1263-71. doi: 10.1016/j.jhep.2015.07.002. Epub 2015 Jul 10.
6
Platelets, inflammation and tissue regeneration.血小板、炎症与组织再生。
Thromb Haemost. 2011 May;105 Suppl 1:S13-33. doi: 10.1160/THS10-11-0720. Epub 2011 Apr 11.
7
Platelets in liver disease, cancer and regeneration.肝脏疾病、癌症与再生中的血小板
World J Gastroenterol. 2017 May 14;23(18):3228-3239. doi: 10.3748/wjg.v23.i18.3228.
8
Autologous platelets as a source of proteins for healing and tissue regeneration.自体血小板作为用于愈合和组织再生的蛋白质来源。
Thromb Haemost. 2004 Jan;91(1):4-15. doi: 10.1160/TH03-07-0440.
9
The Impact of Liver Graft Injury on Cancer Recurrence Posttransplantation.肝移植供肝损伤对移植后癌症复发的影响。
Transplantation. 2017 Nov;101(11):2665-2670. doi: 10.1097/TP.0000000000001844.
10
Risk of posttransplant hepatocellular carcinoma recurrence is greater in recipients with higher platelet counts in living donor liver transplantation.在活体肝移植中，血小板计数较高的受者发生移植后肝细胞癌复发的风险更高。
Liver Transpl. 2018 Jan;24(1):44-55. doi: 10.1002/lt.24961. Epub 2017 Dec 8.
引用本文的文献
1
Approaching Thrombospondin-1 as a Potential Target for Mesenchymal Stromal Cells to Support Liver Regeneration after Partial Hepatectomy in Mouse and Humans.探讨血小板反应蛋白-1 作为间充质基质细胞的潜在靶点，以支持肝部分切除术后在小鼠和人类肝脏再生。
Cells. 2024 Mar 17;13(6):529. doi: 10.3390/cells13060529.
2
Dualistic role of platelets in living donor liver transplantation: Are they harmful?血小板在活体肝移植中的双重作用：它们有害吗？
World J Gastroenterol. 2022 Mar 7;28(9):897-908. doi: 10.3748/wjg.v28.i9.897.
本文引用的文献
1
Association of Platelet Count and Platelet Transfusion With Serotonin Level During Living Donor Liver Transplantation: Possible Connection to Graft Regeneration.活体肝移植期间血小板计数和血小板输注与血清素水平的关联：与移植物再生的可能联系
Transplant Proc. 2018 May;50(4):1104-1107. doi: 10.1016/j.transproceed.2018.02.035.
2
Risk of posttransplant hepatocellular carcinoma recurrence is greater in recipients with higher platelet counts in living donor liver transplantation.在活体肝移植中，血小板计数较高的受者发生移植后肝细胞癌复发的风险更高。
Liver Transpl. 2018 Jan;24(1):44-55. doi: 10.1002/lt.24961. Epub 2017 Dec 8.
3
Association Between Intraoperative Platelet Transfusion and Early Graft Regeneration in Living Donor Liver Transplantation.活体肝移植术中血小板输注与早期移植物再生之间的关联
Ann Surg. 2016 Dec;264(6):1065-1072. doi: 10.1097/SLA.0000000000001526.
4
Involvement of platelets in tumor cell metastasis.血小板在肿瘤细胞转移中的作用。
Pharmacol Ther. 2016 Jan;157:112-9. doi: 10.1016/j.pharmthera.2015.11.005. Epub 2015 Nov 23.
5
Clinical implications of basic research in hepatocellular carcinoma.肝细胞癌基础研究的临床意义
J Hepatol. 2016 Mar;64(3):736-45. doi: 10.1016/j.jhep.2015.09.008. Epub 2015 Oct 9.
6
A focus on the role of platelets in liver regeneration: Do platelet-endothelial cell interactions initiate the regenerative process?关注血小板在肝再生中的作用：血小板-内皮细胞相互作用是否启动了再生过程？
J Hepatol. 2015 Nov;63(5):1263-71. doi: 10.1016/j.jhep.2015.07.002. Epub 2015 Jul 10.
7
Bioreactance Is Not Interchangeable with Thermodilution for Measuring Cardiac Output during Adult Liver Transplantation.在成人肝移植过程中，生物反应性与热稀释法在测量心输出量方面不可互换。
PLoS One. 2015 May 27;10(5):e0127981. doi: 10.1371/journal.pone.0127981. eCollection 2015.
8
Pretreatment platelet count early predicts extrahepatic metastasis of human hepatoma.治疗前血小板计数可早期预测人类肝癌的肝外转移。
Liver Int. 2015 Oct;35(10):2327-36. doi: 10.1111/liv.12817. Epub 2015 Apr 10.
9
Inflammation-based scores do not predict post-transplant recurrence of hepatocellular carcinoma in patients within Milan criteria.基于炎症的评分无法预测米兰标准内患者肝移植后肝细胞癌的复发情况。
Liver Transpl. 2014 Nov;20(11):1327-35. doi: 10.1002/lt.23969.
10
Leukoreduced blood transfusion does not increase circulating soluble markers of inflammation: a randomized controlled trial.去白细胞输血不会增加循环中可溶性炎症标志物：一项随机对照试验。
Transfusion. 2014 Oct;54(10):2404-11. doi: 10.1111/trf.12669. Epub 2014 May 5.
Zotero 插件