Ophthalmology Department, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Ann Palliat Med. 2021 Jul;10(7):7857-7865. doi: 10.21037/apm-21-1303.
This research explored the efficacy and safety of IPL in the treatment of dry eye caused by Meibomian gland dysfunction (MGD).
A total of 132 patients with dry eye caused by MGD were enrolled in this study. The patients were randomly divided into either the experimental group or the control group by random number table. The experimental group (n=66) was treated with intense pulsed light (IPL), and the control group (n=66) was treated with palpebral gland massage combined with a hot compress. The efficacy, the incidence of adverse events, and patients' levels of satisfaction with treatment were compared between the 2 groups. The quality score of the palpebral gland, the height of the lacrimal river, and the change of tear secretion function were analyzed using a generalized linear equation at different time points.
The total effective rates of experimental group and control group were 90.2% and 80.0%, respectively, and the therapeutic effects of experimental group were better than those of the control group (P<0.05). In the generalized estimation equation, with the passing of time, the eyelid gland quality score for moderate and severe abnormality, the lacrimal river height measurements ≤0.35 mm, and the tear secretion measurements ≤5 mm all decreased (P<0.05). In addition, the moderate and severe abnormal eyelid gland quality score, the lacrimal river height measurements ≤0.35 mm and the tear secretion measurements≤5 mm of patients in the experimental group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse events between two groups during treatment (P>0.05). In the satisfaction survey, patients who received IPL treatment had higher levels of satisfaction at 7 days and 30 days than those control group (P<0.05).
IPL is more effective in the treatment of eyelid gland dysfunction dry eye than a traditional eyelid gland massage combined with a hot compress. IPL effectively improves eye function and alleviates clinical symptoms and has good safety; thus, it can be considered for clinical application and promotion.
This study has been registered on the Chinese Clinical Trial Registry (ChiCTR2100045886).
本研究旨在探讨强脉冲光（IPL）治疗睑板腺功能障碍（MGD）所致干眼症的疗效和安全性。
本研究共纳入 132 例 MGD 所致干眼症患者，采用随机数字表法将其分为实验组和对照组，每组 66 例。实验组采用 IPL 治疗，对照组采用睑板腺按摩联合热敷治疗。比较两组患者的疗效、不良反应发生率及治疗满意度。采用广义线性方程分析不同时间点的睑板腺质量评分、泪河高度和泪液分泌功能变化。
实验组和对照组的总有效率分别为 90.2%和 80.0%，实验组的治疗效果优于对照组（P<0.05）。在广义估计方程中，随着时间的推移，中重度异常睑板腺质量评分、泪河高度测量值≤0.35mm 和泪液分泌测量值≤5mm 均降低（P<0.05）。此外，实验组中中重度异常睑板腺质量评分、泪河高度测量值≤0.35mm 和泪液分泌测量值≤5mm 的患者均低于对照组（P<0.05）。两组患者治疗期间不良反应发生率差异无统计学意义（P>0.05）。在满意度调查中，接受 IPL 治疗的患者在 7 天和 30 天的满意度均高于对照组（P<0.05）。
与传统的睑板腺按摩联合热敷相比，IPL 治疗睑板腺功能障碍性干眼症更有效。IPL 能有效改善眼功能，缓解临床症状，且安全性良好；因此，可考虑临床应用和推广。
本研究已在中国临床试验注册中心（ChiCTR2100045886）注册。
