Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Rd, Hefei, Anhui Province, China.
BMC Infect Dis. 2021 Aug 5;21(1):761. doi: 10.1186/s12879-021-06463-3.
To identify the correlation between the level of at-admission fasting blood glucose (FBG) with poor outcomes in hospitalized patients suffering from severe fever with thrombocytopenia syndrome (SFTS).
Between April 1 and December 1, 2020, the list of hospitalized patients affected with SFTS infection was provided by the Infectious Disease Department at First Affiliated Hospital of Anhui Medical University, followed by the collection of information I.e., gender, age, diabetic history and the level of FBG on admission.
In this study, a total of 77 patients were included and were categorized into three groups (< 5.6, 5.6-6.9, and ≥ 7.0 mmol/l) on the basis of their glucose level in the blood. The obtained results revealed that among three groups considerable variations were observed in leukocytes, FBG, D-Dimer, aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α), fibrin degradation products (FDP), and interleukin (IL)-10 level. Correlation analysis indicated a linear negative correlation between PLT and FBG (r = - 0.28, P = 0.01), however, a linear positive correlation was observed between AST, IL10, D-Dimer, and FDP levels and FBG (P-value < 0.05). Multivariate statistical analysis results shown that there was significant difference between group comparison (F = 17.01, P < 0.001) and interaction between group and time (F = 8.48, P < 0.05); but there was no significant difference between time point comparison (F = 0.04, P = 0.96). With the prolongation of time, the changes of FBG were different between survivor group and non-survivor group. The FBG in survival group shown a downward trend; The non-survivor group shown an upward trend.
Elevated level of FBG has been correlated with hypercoagulability, inflammation, and lower PLT in SFTS patients. The measurement of FBG level can help in evaluating the inflammatory process, hypercoagulability, and prognosis of patients suffering from SFTS. FBG can predict the prognosis of SFTS. It is necessary to pay attention to the role of FBG in the process of treatment in patients with SFTS.
探讨入院时空腹血糖（FBG）水平与严重发热伴血小板减少综合征（SFTS）住院患者不良预后的相关性。
2020 年 4 月 1 日至 12 月 1 日，安徽医科大学第一附属医院感染科提供了 SFTS 感染住院患者名单，随后收集了患者的信息，包括性别、年龄、糖尿病史和入院时的 FBG 水平。
本研究共纳入 77 例患者，根据血糖水平分为三组（<5.6mmol/L、5.6-6.9mmol/L 和≥7.0mmol/L）。结果显示，三组间白细胞、FBG、D-二聚体、天门冬氨酸氨基转移酶（AST）、肿瘤坏死因子-α（TNF-α）、纤维蛋白降解产物（FDP）和白细胞介素（IL）-10 水平差异有统计学意义。相关性分析显示，PLT 与 FBG 呈线性负相关（r=-0.28，P=0.01），AST、IL-10、D-二聚体和 FDP 水平与 FBG 呈线性正相关（P 值均<0.05）。多因素统计分析结果显示，组间比较差异有统计学意义（F=17.01，P<0.001），组间和时间的交互作用差异有统计学意义（F=8.48，P<0.05）；但时间点比较差异无统计学意义（F=0.04，P=0.96）。随着时间的延长，幸存者组和非幸存者组 FBG 的变化不同。生存组 FBG 呈下降趋势，而非幸存者组呈上升趋势。
SFTS 患者入院时 FBG 升高与高凝状态、炎症和血小板计数降低有关。检测 FBG 水平有助于评估 SFTS 患者的炎症过程、高凝状态和预后。FBG 可预测 SFTS 的预后。在 SFTS 患者的治疗过程中，需要注意 FBG 的作用。
