Epidemiology of Highly Pathogenic Microorganisms, Robert Koch-Institute, Berlin, Germany; Viral Evolution, Robert Koch-Institute, Berlin, Germany.
Epidemiology of Highly Pathogenic Microorganisms, Robert Koch-Institute, Berlin, Germany; Viral Evolution, Robert Koch-Institute, Berlin, Germany.
Adv Virus Res. 2021;110:1-26. doi: 10.1016/bs.aivir.2021.06.001. Epub 2021 Jul 8.
Over the last two decades, the viromes of our closest relatives, the African great apes (AGA), have been intensively studied. Comparative approaches have unveiled diverse evolutionary patterns, highlighting both stable host-virus associations over extended evolutionary timescales and much more recent viral emergence events. In this chapter, we summarize these findings and outline how they have shed a new light on the origins and evolution of many human-infecting viruses. We also show how this knowledge can be used to better understand the evolution of human health in relation to viral infections.
在过去的二十年中，我们最亲近的亲属——非洲大猿（AGA）的病毒组得到了深入研究。比较方法揭示了多样化的进化模式，强调了在较长的进化时间尺度上稳定的宿主-病毒关联，以及更近的病毒出现事件。在本章中，我们总结了这些发现，并概述了它们如何为许多感染人类的病毒的起源和进化提供了新的认识。我们还展示了如何利用这些知识更好地理解人类健康与病毒感染之间的进化关系。
