Department of Pathology, VU University Medical Centre Amsterdam, Amsterdam, The Netherlands.
Department of Diagnostic Pathology, National Cancer Centre Hospital, Tokyo, Japan.
Histopathology. 2022 Feb;80(3):457-467. doi: 10.1111/his.14537. Epub 2021 Sep 23.
Elastin and collagen are the main components of the lung connective tissue network, and together provide the lung with elasticity and tensile strength. In pulmonary pathology, elastin staining is used to variable extents in different countries. These uses include evaluation of the pleura in staging, and the distinction of invasion from collapse of alveoli after surgery (iatrogenic collapse). In the latter, elastin staining is used to highlight distorted but pre-existing alveolar architecture from true invasion. In addition to variable levels of use and experience, the interpretation of elastin staining in some adenocarcinomas leads to interpretative differences between collapsed lepidic patterns and true papillary patterns. This review aims to summarise the existing data on the use of elastin staining in pulmonary pathology, on the basis of literature data and morphological characteristics. The effect of iatrogenic collapse and the interpretation of elastin staining in pulmonary adenocarcinomas is discussed in detail, especially for the distinction between lepidic patterns and papillary carcinoma.
弹性蛋白和胶原是肺结缔组织网络的主要成分，它们共同为肺提供弹性和拉伸强度。在肺病理学中，弹性蛋白染色在不同国家的应用程度不同。这些应用包括分期时胸膜的评估，以及手术后（医源性塌陷）肺泡塌陷与浸润的区分。在后一种情况下，弹性蛋白染色用于突出扭曲但预先存在的肺泡结构与真正的浸润。除了使用和经验水平的差异外，一些腺癌中弹性蛋白染色的解释导致塌陷的鳞屑样模式和真正的乳头状模式之间存在解释上的差异。本综述旨在根据文献数据和形态学特征，总结弹性蛋白染色在肺病理学中的应用现有数据。详细讨论了医源性塌陷的影响以及肺腺癌中弹性蛋白染色的解释，特别是在鳞屑样模式和乳头状癌之间的区分。
