Charles Perkins Centre, The University of Sydney, 2006 Sydney, NSW, Australia; School of Life and Environmental Sciences, The University of Sydney, 2006 Sydney, NSW, Australia.
Charles Perkins Centre, The University of Sydney, 2006 Sydney, NSW, Australia; School of Life and Environmental Sciences, The University of Sydney, 2006 Sydney, NSW, Australia; Bosch Institute, The University of Sydney, 2006 Sydney, NSW, Australia; Sydney Nano Institute, The University of Sydney, 2006 Sydney, NSW, Australia.
Matrix Biol. 2019 Nov;84:4-16. doi: 10.1016/j.matbio.2019.07.005. Epub 2019 Jul 10.
Elastic fibers are an essential component of the extracellular matrix where they provide structural integrity and elastic recoil in a number of important tissues. A major constituent of these fibers is elastin, an insoluble metabolically stable polymer formed via extensive crosslinking of the monomeric precursor tropoelastin. Research over the past few decades has shown that tropoelastin possesses unique structural features that differ from both intrinsically disordered and globular proteins. This review details the advances in our understanding of tropoelastin's structural properties and illustrates how these dictate its biological function.
弹性纤维是细胞外基质的重要组成部分，为多种重要组织提供结构完整性和弹性回弹。这些纤维的主要成分是弹性蛋白，这是一种不溶性的代谢稳定聚合物，通过单体前体原弹性蛋白的广泛交联形成。过去几十年的研究表明，原弹性蛋白具有独特的结构特征，与无规卷曲和球状蛋白均不同。本综述详细介绍了我们对原弹性蛋白结构特性的理解进展，并说明了这些特性如何决定其生物学功能。
