夫西地酸在离体大鼠肝细胞中的多价抑制作用。
Polyvalent inhibitory action of fusidic acid in isolated rat liver cells.
作者信息
Muñoz R, Ferreras J M, Alonso P, Vaquera J, Girbés T
机构信息
Departamento de Bioquímica, Biología Molecular y Fisiología, Facultad de Ciencias, Universidad de Valladolid, Spain.
出版信息
Biochem Int. 1987 Nov;15(5):1013-9.
The steroidic antibiotic fusidic acid showed a polyvalent action on isolated rat liver cells. It displayed a strong inhibitory capability on protein synthesis in intact cells even stronger than that previously reported in cell-free extracts. Also, it inhibited basal gluconeogenesis and promoted an increase of the membrane permeability to trypan blue. However, the effects on both protein synthesis and basal gluconeogenesis were observed at doses smaller than those required to reduce the cell viability.
甾体抗生素夫西地酸对分离的大鼠肝细胞具有多价作用。它对完整细胞中的蛋白质合成表现出很强的抑制能力，甚至比先前在无细胞提取物中报道的还要强。此外，它抑制基础糖异生，并促进细胞膜对台盼蓝的通透性增加。然而，对蛋白质合成和基础糖异生的影响是在低于降低细胞活力所需剂量时观察到的。
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